Bleomycin-induced Pneumonitis in a Child Treated With Nintedanib: Report of the First Case in a Childhood

被引:2
|
作者
Gundogan, Begumhan D. [1 ]
Taskinlar, Simge [4 ]
Arikoglu, Tuba [2 ]
Balci, Yuksel [3 ]
Citak, Elvan C. [1 ]
机构
[1] Mersin Univ, Fac Med, Dept Pediat Oncol, TR-33110 Mersin, Turkey
[2] Mersin Univ, Fac Med, Dept Pediat Allergy & Immunol, Mersin, Turkey
[3] Mersin Univ, Fac Med, Dept Radiol, Mersin, Turkey
[4] Mersin City Hosp, Dept Pediat Hematol & Oncol, Mersin, Turkey
关键词
nindetanib; bleomycin-induced pneumonia; children; pulmonary fibrosis; PULMONARY TOXICITY; CANCER; MODELS;
D O I
10.1097/MPH.0000000000002266
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Pulmonary fibrosis caused by bleomycin-induced pneumonia (BIP) is the most important side effect limiting the use of bleomycin and is mainly treated with corticosteroids. However, 1% to 4% of patients do not respond to corticosteroid therapy. Idiopathic pulmonary fibrosis and BIP develop by similar pathophysiological mechanisms. Nintedanib is a tyrosine kinase inhibitor used successfully in the treatment of idiopathic pulmonary fibrosis and there is no information about its use in BIP treatment. Here, we would like to present a 13-year-old boy with Hodgkin lymphoma who developed BIP after 2 cycles of ABVD (Adriamycin, bleomycin, vinblastine, and dacarbazine) and 4 cycles of BAECOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone), whose respiratory failure impaired despite corticosteroid therapy, but was successfully treated with nintedanib.
引用
收藏
页码:E500 / E502
页数:3
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