Bleomycin-induced Pneumonitis in a Child Treated With Nintedanib: Report of the First Case in a Childhood

被引:2
|
作者
Gundogan, Begumhan D. [1 ]
Taskinlar, Simge [4 ]
Arikoglu, Tuba [2 ]
Balci, Yuksel [3 ]
Citak, Elvan C. [1 ]
机构
[1] Mersin Univ, Fac Med, Dept Pediat Oncol, TR-33110 Mersin, Turkey
[2] Mersin Univ, Fac Med, Dept Pediat Allergy & Immunol, Mersin, Turkey
[3] Mersin Univ, Fac Med, Dept Radiol, Mersin, Turkey
[4] Mersin City Hosp, Dept Pediat Hematol & Oncol, Mersin, Turkey
关键词
nindetanib; bleomycin-induced pneumonia; children; pulmonary fibrosis; PULMONARY TOXICITY; CANCER; MODELS;
D O I
10.1097/MPH.0000000000002266
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Pulmonary fibrosis caused by bleomycin-induced pneumonia (BIP) is the most important side effect limiting the use of bleomycin and is mainly treated with corticosteroids. However, 1% to 4% of patients do not respond to corticosteroid therapy. Idiopathic pulmonary fibrosis and BIP develop by similar pathophysiological mechanisms. Nintedanib is a tyrosine kinase inhibitor used successfully in the treatment of idiopathic pulmonary fibrosis and there is no information about its use in BIP treatment. Here, we would like to present a 13-year-old boy with Hodgkin lymphoma who developed BIP after 2 cycles of ABVD (Adriamycin, bleomycin, vinblastine, and dacarbazine) and 4 cycles of BAECOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone), whose respiratory failure impaired despite corticosteroid therapy, but was successfully treated with nintedanib.
引用
收藏
页码:E500 / E502
页数:3
相关论文
共 50 条
  • [1] Nintedanib treatment for bleomycin-induced lung injury - First report
    Rnjak, Dina
    Hadar, Martina Batarilo
    Pelicaric, Dubravka
    Vukic, Tea
    Makek, Mateja Jankovic
    Samarzija, Miroslav
    Hecimovic, Ana
    RESPIRATORY MEDICINE CASE REPORTS, 2023, 46
  • [2] Bleomycin-induced pneumonitis
    Sleijfer, S
    CHEST, 2001, 120 (02) : 617 - +
  • [3] Bleomycin-induced pneumonitis in three patients treated with chemotherapy for primary advanced seminoma
    Stein, Moshe E.
    Zidan, Jamal
    Charas, Tomer
    Gershuny, Anthony
    Ben-Yosef, Rahamim
    JOURNAL OF BUON, 2015, 20 (03): : 928 - 932
  • [4] Bleomycin-induced Flagellated dermatitis: a case report
    Stevens G, Jonathan
    Dossi C, Maria Teresa
    Munoz M, Gianna
    REVISTA CHILENA DE PEDIATRIA-CHILE, 2018, 89 (02): : 257 - 260
  • [5] Bleomycin-induced upper lobe fibrosis: A case report
    Marruchella, A
    Franco, C
    Garavaldi, G
    Uccelli, M
    Bottrighi, P
    TUMORI, 2002, 88 (05) : 414 - 416
  • [6] Bleomycin-induced pulmonary toxicity and treatment with infliximab: A case report
    Ge, Victor
    Banakh, Iouri
    Tiruvoipati, Ravindranath
    Haji, Kavi
    CLINICAL CASE REPORTS, 2018, 6 (10): : 2011 - 2014
  • [7] Impact of Granulocyte-colony Stimulating Factor on Bleomycin-induced Pneumonitis in Chemotherapy-treated Germ Cell Tumors
    Kwan, Edmond M.
    Beck, Sophie
    Amir, Eitan
    Jewett, Michael A.
    Sturgeon, Jeremy F.
    Anson-Cartwright, Lynn
    Chung, Peter W.
    Warde, Padraig R.
    Moore, Malcolm J.
    Bedard, Philippe L.
    Tran, Ben
    CLINICAL GENITOURINARY CANCER, 2018, 16 (01) : E193 - E199
  • [8] A case of bleomycin-induced lung toxicity
    Tetikkurt, Cuneyt
    Ongel, Deniz
    Tetikkurt, Seza
    MONALDI ARCHIVES FOR CHEST DISEASE, 2018, 88 (03) : 30 - 33
  • [9] Prognostic impact of bleomycin-induced pneumonitis on the outcome of Hodgkin's lymphoma
    Ngeow, Joanne
    Tan, Iain B.
    Kanesvaran, Ravindran
    Tan, Huey Ching
    Tao, Miriam
    Quek, Richard
    Lim, Soon Thye
    ANNALS OF HEMATOLOGY, 2011, 90 (01) : 67 - 72
  • [10] Nintedanib Reduces Neutrophil Chemotaxis via Activating GRK2 in Bleomycin-Induced Pulmonary Fibrosis
    Chen, Wei-Chih
    Chen, Nien-Jung
    Chen, Hsin-Pai
    Yu, Wen-Kuang
    Su, Vincent Yi-Fong
    Chen, Hao
    Wu, Huai-Hsuan
    Yang, Kuang-Yao
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (13) : 1 - 16