Regio- and Stereoselective Alkylboration of Endocyclic Olefins Enabled by Nickel Catalysis

被引:65
作者
Ding, Chao [1 ]
Ren, Yaoyu [1 ]
Sun, Caocao [1 ]
Long, Jiao [1 ]
Yin, Guoyin [1 ]
机构
[1] Wuhan Univ, Inst Adv Studies, Wuhan 430072, Hubei, Peoples R China
基金
中国国家自然科学基金;
关键词
C(SP(3))-H ALPHA-ALKYLATION; C-H ALKYLATION; ASYMMETRIC ARYLATION; PALLADIUM; CYCLOADDITION; ALKENES; FUNCTIONALIZATION; TETRAHYDROPYRANS; HYDROARYLATION; ARYLBORATION;
D O I
10.1021/jacs.1c09214
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Whereas there is a significant interest in the rapid construction of diversely substituted saturated heterocycles, direct and modular access is currently limited to the mono-, 2,3-, or 3,4-substitution pattern. This Communication describes the straightforward and modular construction of 2,4-substituted saturated heterocycles from readily available materials in a highly stereo- and regioselective manner, which sets the stage for numerous readily accessible drug motifs. The strategy relies on chain walking catalysis.
引用
收藏
页码:20027 / 20034
页数:8
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