Metformin Use Was Associated With Reduced Risk of Incidental Sjogren's Syndrome in Patients With Type 2 Diabetes: A Population-Based Cohort Study

Purpose: Previous studies have shown that metformin exhibits an anti-inflammatory effect and may decrease the risk of incidental diabetes. But the effect of metformin on incidental Sjogren's syndrome is unknown. The aim of the study was to examine the association between metformin exposure and Sjogren's syndrome in diabetic patients.Methods: The dataset in this retrospective cohort study was obtained from the National Health Insurance Research Database (2000-2013) in Taiwan. In total, 15,098 type 2 diabetic patients under metformin treatment and an equivalent number without metformin treatment matched for comparison were included. The primary endpoint was the incidence of Sjogren's syndrome. Univariate and multivariate Cox proportional hazards models were used for data analysis. A subgroup analysis and sensitivity test were also performed.Results: The incidence rate of Sjogren's syndrome in non-metformin controls was 40.83 per 100,000 person-years and 16.82 per 100,000 person-years in metformin users. The adjusted hazard ratio (aHR) in diabetic patients under metformin treatment was 0.46 (95% CI, 0.23 to 0.92). In subgroup analysis, men had a lower risk of developing Sjogren's syndrome than women [aHR = 0.15, 95% CI = (0.05, 0.41)]. After prescribing metformin to type 2 diabetic patients aged 60 years or more, those patients had a lower risk of developing Sjogren's syndrome [aHR = 0.34, 95% CI = (0.12, 0.96)].Conclusion: In this large population-based cohort study, metformin exposure was associated with a reduced risk of developing Sjogren's syndrome in type 2 diabetic patients.