Solubility and thermodynamic functions of cefazolin acid in pure and mixed solvents at (278.15-30815)K

被引：21
|
作者：
Zhang, Jiao [1 ]
Ouyang, Jinbo [1 ]
Zhang, Hongjiao [1 ]
Huang, Xin [1 ]
Hao, Hongxun [1 ,2 ]
Wang, Yongli [1 ,2 ]
Yin, Qiuxiang [1 ,2 ]
Fang, Wen [3 ]
机构：
[1] Tianjin Univ, Sch Chem Engn & Technol, State Key Lab Chem Engn, Tianjin 300072, Peoples R China
[2] Collaborat Innovat Ctr Chem Sci & Chem Engn, Tianjin 300072, Peoples R China
[3] Nanjing Lifenergy R&D Co Ltd, Nanjing 210016, Jiangsu, Peoples R China
来源：
FLUID PHASE EQUILIBRIA | 2015年 / 387卷
基金：
中国国家自然科学基金;
关键词：
Cefazolin acid; UV spectrometer; Solubility; Thermodynamic properties; ORGANIC-COMPOUNDS; MELTING-POINTS; ENTHALPY; ENTROPY; LIQUIDS; WATER;
D O I：
10.1016/j.fluid.2014.12.020
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
Solvent screening is of great importance in the design and optimization of drug crystallization. In this paper, the solubility data of cefazolin acid in five pure solvents and one binary solvent mixtures (N, N-dimethylformamide + 2-propanol) were experimentally measured in temperature range from (278.15-308.15) K by using UV spectrometer method. The melting temperature of cefazolin acid was estimated by three-level group contribution method. All the experimental solubility data were correlated by the modified Apelblat model and the lambda h equation. The experimental solubility data in binary solvent mixtures were also correlated by the nearly ideal binary solvent CNIBS/Redlich-Kister model. In addition, based on the modified van't Hoff equation, the thermodynamic properties of cefazolin acid dissolution process were also calculated and discussed. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：95 / 102
页数：8
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