Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Healthcare Workers before the Era of Vaccination at a Tertiary Care Hospital in Turkey

被引：7

作者：

Sonmezer, Meliha Cagla ^{[1
]}

Erul, Enes ^{[2
]}

Sahin, Taha Koray ^{[2
]}

Rudvan Al, Ipek ^{[1
]}

Cosgun, Yasemin ^{[3
]}

Korukluoglu, Gulay ^{[3
]}

Zengin, Humeyra ^{[1
]}

Telli Dizman, Guelcin ^{[1
]}

Inkaya, Ahmet Cagkan ^{[1
]}

Unal, Serhat ^{[1
]}

机构：

[1] Hacettepe Univ, Infect Dis & Clin Microbiol Dept, Fac Med, TR-06100 Ankara, Turkey

[2] Hacettepe Univ, Internal Med Dept, Fac Med, TR-06100 Ankara, Turkey

[3] Natl Arboviruses & Viral Zoonot Dis Lab, Microbiol Reference Labs Dept, Publ Hlth Gen Directorate Turkey, TR-06100 Ankara, Turkey

来源：

VACCINES | 2022年 / 10卷 / 02期

关键词：

COVID-19; healthcare workers; before vaccination; seroprevalence; SARS-Co-V; 2; antibody; INFECTION; COVID-19; RISK;

D O I：

10.3390/vaccines10020258

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Healthcare workers (HCWs), as frontliners, are assumed to be among the highest risk groups for COVID-19 infection, especially HCWs directly involved in patient care. However, the data on the COVID-19 infection and seroprevalence rates are limited in HCWs. Therefore, we aimed to evaluate the seroprevalence rates in HCWs according to risk groups for COVID-19 contraction in a large cross-sectional study from a tertiary care hospital in Turkey. We enrolled 1974 HCWs before the vaccination programs. In two separate semi-quantitative ELISAs, either IgA or IgG antibodies against SARS-CoV-2 spike protein subunit 1 (S1) were measured. The proportion of positive test results for IgG, IgA, or both against SARS-CoV-2 of study subjects was 19% (375/1974). Frontline HCWs who had contact with patients (21.7%, RR 2.1 [1.51-2.92]) and HCWs in working in the COVID-19 units, intensive care units, or emergency department (19.7%, RR 1.61 [1.12-2.32]) had a notably higher Anti-SARS-CoV-2 IgG compared to the rest of HCWs who has no daily patient contacts ([11.1%]; p < 0.0001). HCWs who care for regular patients in the medium-risk group have also experienced a sustained higher risk of exposure to SARS-CoV-2. We should enhance the precaution against COVID-19 to protect HCW's safety through challenging times.

引用

页数：9