ATM mutations in B-cell chronic lymphocytic leukemia

被引：1

作者：

Lähdesmäki, A ^{[3
]}

机构：

[1] UCL Royal Free & Univ Coll, Sch Med, Dept Hematol, London NW3 2PF, England

[2] Univ Hosp, Karolinska Inst Huddinge, Dept Med, Div Hematol, SE-14186 Stockholm, Sweden

[3] Novum, Ctr Biotechnol, SE-14157 Huddinge, Sweden

[4] Huddinge Univ Hosp, Karolinska Inst Huddinge, Dept Lab Med, Div Clin Immunol, SE-14186 Stockholm, Sweden

来源：

HAEMATOLOGICA | 2004年 / 89卷 / 01期

关键词：

ATM mutations; ataxia-telongiectasia; B-cell chronic lymphocytic leukemia;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tumor DNA samples from 56 patients with sporadic B-CLL chronic lymphocytic leukemia (B-CLL) were analyzed for mutations in the ATM gene, using exon scanning single strand conformation polymorphism (SSCP). Fifteen patients (27%) showed a pattern compatible with the presence of a somatic mutation. In only five patients, however, was a mutation possibly associated with the disease status detected, suggesting that ATM mutations make only a minor contribution to the pathogenesis of B-CLL.

引用

页码：109 / 110

页数：2

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