99mTc-ciprofloxacin in imaging of clinical infections in camelids and a goat

被引:3
作者
Alexander, K [1 ]
Drost, WT [1 ]
Mattoon, JS [1 ]
Anderson, DE [1 ]
机构
[1] Ohio State Univ, Coll Vet Med, Dept Vet Clin Sci, Columbus, OH 43210 USA
关键词
alpaca; infection imaging; llama; Tc-99m-ciprofloxacin; scintigraphy;
D O I
10.1111/j.1740-8261.2005.00064.x
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
99(m)Tc-ciprofloxacin was used to image five adult camelids and a juvenile goat with clinical and/or radiographic signs of infection. 99(m)Tc-ciprofloxacin (range 10-33 MBq/kg) was injected intravenously and a series of 2-min static images were acquired at 1- and 4-h postinjection. At 24-h postinjection, 5-min static images were acquired. Only the skull or abdomen was imaged in the adults; the whole body was imaged in the goat. The quality of the 1-, 4-, and 24-h studies was evaluated subjectively. Normal and abnormal areas of 99(m)Tc-ciprofloxacin uptake were recorded and subjectively graded as mild, moderate or intense. Image quality was best 4-h postinjection. Twenty-four-hour images were poor because of insufficient radioactivity. 99mTc-ciprofloxacin imaging resulted in true positive or true negative scans in four of six animals. Two false-negative studies occurred. Intense 99(m)Tc-ciprofloxacin activity was seen in the lungs and urinary bladder, moderate/intense activity in the kidneys, and mild activity in the physes/epiphyses, liver and intermittently in the gastrointestinal tract. The normal distribution of 99(m)Tc-ciprofloxacin in camelids/small ruminants differed from people. Further studies to determine the sensitivity and specificity of infection detection using Tc-99m-ciprofloxacin in animals are warranted.
引用
收藏
页码:340 / 347
页数:8
相关论文
共 55 条
[1]   Evaluation of technetium-99m-ciprofloxacin (Infecton) for detecting sites of inflammation in arthritis [J].
Appelboom, T ;
Emery, P ;
Tant, L ;
Dumarey, N ;
Schoutens, A .
RHEUMATOLOGY, 2003, 42 (10) :1179-1182
[2]  
Awasthi V, 1998, J NUCL MED, V39, P1089
[3]   Radiopharmaceuticals for scintigraphic imaging of infection and inflammation [J].
Boerman, OC ;
Dams, ETM ;
Oyen, WJG ;
Corstens, FHM ;
Storm, G .
INFLAMMATION RESEARCH, 2001, 50 (02) :55-64
[4]  
Britton KE, 1997, EUR J NUCL MED, V24, P553
[5]   Imaging bacterial infection with 99mTc-ciprofloxacin (Infecton) [J].
Britton, KE ;
Wareham, DW ;
Das, SS ;
Solanki, KK ;
Amaral, H ;
Bhatnagar, A ;
Katamihardja, AHS ;
Malamitsi, J ;
Moustafa, HM ;
Soroa, VE ;
Sundram, FX ;
Padhy, AK .
JOURNAL OF CLINICAL PATHOLOGY, 2002, 55 (11) :817-823
[6]  
Cebra ML, 1996, J AM VET MED ASSOC, V209, P819
[7]  
CHAMBERS MD, 1996, HDB VET NUCL MED, P49
[8]   Imaging pelvic inflammatory disease with Tc-99m ciprofloxacin [J].
Choe, W ;
Im, MW ;
Chung, JK ;
Jeong, JM .
CLINICAL NUCLEAR MEDICINE, 2000, 25 (10) :842-844
[9]   Imaging prostatitis with Tc-99m ciprofloxacin [J].
Choe, W ;
Chung, MH ;
Kim, WH ;
Kim, S ;
Ryu, JK ;
Kang, KJ ;
Suh, JK .
CLINICAL NUCLEAR MEDICINE, 2002, 27 (07) :527-529
[10]  
CORSTENS FHM, 1991, J NUCL MED, V32, P491