An efficient one-pot method for the synthesis of novel ferrocene-triamide conjugates via pseudo five-component reaction

A simple and efficient one-pot synthesis of novel ferrocene-triamide conjugates from the reaction of ferrocenecarboxaldehyde with Meldrum's acid and isocyanides in the presence of NH-containing compounds is described. This transformation proceeds through the creation of two C-C bonds, two C-N bonds, and one C=O bond, leading to three peptide bonds, and presumably occurs via a domino sequence involving Knoevenagel condensation, [1+4] cycloaddition, deacetonation, and aminolysis reactions. (C) 2011 Elsevier Ltd. All rights reserved.