An efficient one-pot method for the synthesis of novel ferrocene-triamide conjugates via pseudo five-component reaction

被引：16

作者：

Teimouri, Mohammad Bagher ^{[1
]}

Akbari-Moghaddam, Peyman ^{[1
]}

机构：

[1] Iran Polymer & Petrochem Inst, Petrochem Dept, Tehran, Iran

来源：

TETRAHEDRON | 2011年 / 67卷 / 33期

关键词：

Ferrocene-amide conjugate; Isocyanide; Meldrum's acid; Multicomponent reaction; ISOPROPYLIDENE MELDRUMS ACID; ORGANOMETALLIC ANALOG; ALKYL ISOCYANIDES; FACILE SYNTHESIS; DRUG DISCOVERY; DERIVATIVES;

D O I：

10.1016/j.tet.2011.06.048

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient one-pot synthesis of novel ferrocene-triamide conjugates from the reaction of ferrocenecarboxaldehyde with Meldrum's acid and isocyanides in the presence of NH-containing compounds is described. This transformation proceeds through the creation of two C-C bonds, two C-N bonds, and one C=O bond, leading to three peptide bonds, and presumably occurs via a domino sequence involving Knoevenagel condensation, [1+4] cycloaddition, deacetonation, and aminolysis reactions. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：5928 / 5934

页数：7

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