An efficient one-pot method for the synthesis of novel ferrocene-triamide conjugates via pseudo five-component reaction

被引：16
|
作者：
Teimouri, Mohammad Bagher [1 ]
Akbari-Moghaddam, Peyman [1 ]
机构：
[1] Iran Polymer & Petrochem Inst, Petrochem Dept, Tehran, Iran
来源：
TETRAHEDRON | 2011年 / 67卷 / 33期
关键词：
Ferrocene-amide conjugate; Isocyanide; Meldrum's acid; Multicomponent reaction; ISOPROPYLIDENE MELDRUMS ACID; ORGANOMETALLIC ANALOG; ALKYL ISOCYANIDES; FACILE SYNTHESIS; DRUG DISCOVERY; DERIVATIVES;
D O I：
10.1016/j.tet.2011.06.048
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient one-pot synthesis of novel ferrocene-triamide conjugates from the reaction of ferrocenecarboxaldehyde with Meldrum's acid and isocyanides in the presence of NH-containing compounds is described. This transformation proceeds through the creation of two C-C bonds, two C-N bonds, and one C=O bond, leading to three peptide bonds, and presumably occurs via a domino sequence involving Knoevenagel condensation, [1+4] cycloaddition, deacetonation, and aminolysis reactions. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5928 / 5934
页数：7
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