Synthesis of vinyl sulfides via hydrothiolation of alkynes using Al2O3/KF under solvent-free conditions

被引：48
|
作者：
Silva, Marcio S. [1 ]
Lara, Renata G. [1 ]
Marczewski, Junior M. [1 ]
Jacob, Raquel G. [1 ]
Lenardao, Eder J. [1 ]
Perin, Gelson [1 ]
机构：
[1] Univ Fed Pelotas, Inst Quim & Geociencias, LASOL, BR-96010900 Pelotas, RS, Brazil
来源：
TETRAHEDRON LETTERS | 2008年 / 49卷 / 12期
关键词：
solvent-free reaction; hydrothiolation; vinyl sulide;
D O I：
10.1016/j.tetlet.2008.01.093
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We present here a clean, solvent-free hydrothiolation of alkynes using solid supported catalyst (Al(2)O(3)/KF). This efficient and improved method selectively furnishes the corresponding anti-Markovnikov vinyl sulfides in good to excellent yields. The method is applicable for aliphatic and aromatic thiols and the catalytic system can be re-used up to two times without previous treatment and with comparable activity. (c) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1927 / 1930
页数：4
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