Synthesis and Primary Antitumor Screening of 5-Ylidene Derivatives of 3-(Morpholin-4-yl)-2-sulfanylidene-1,3-thiazolidin-4-one

被引：11

作者：

Horishny, V. Ya. ^{[1
]}

Chaban, T. I. ^{[1
]}

Matiychuk, V. S. ^{[2
]}

机构：

[1] Danila Halytsky Lviv Natl Med Univ, UA-79010 Lvov, Ukraine

[2] Ivan Franko Lviv Natl Univ, UA-79005 Lvov, Ukraine

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 56卷 / 03期

关键词：

3-morpholinorhodanine; 5-ylidene-3-(morpholin-4-yl)-2-sulfanylidene-1; 3-thiazolidin-4-ones; antitumor activity; DRUG; RHODANINE; SCAFFOLD;

D O I：

10.1134/S1070428020030148

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A preparative procedure has been developed for the synthesis of 3-(morpholin-4-yl)-2-sulfanylidene-1,3-thiazolidin-4-one (3-morpholinorhodanine). Its reaction with aldehydes afforded a number of previously unknown 5-ylidene derivatives which were screened for antitumor activity. The synthesized compounds showed a moderate activity against most malignant tumor cells. The renal cancer cell lines UO31 and TK10 were found to be most sensitive to all the tested compounds.

引用

页码：454 / 457

页数：4

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