LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis

被引：199

作者：

Wu, Xiang-Song ^{[1
,2
,3
]}

Wang, Fang ^{[4
]}

Li, Huai-Feng ^{[1
,2
,3
]}

Hu, Yun-Ping ^{[1
,2
,3
]}

Jiang, Lin ^{[1
,2
,3
]}

Zhang, Fei ^{[1
,2
,3
]}

Li, Mao-Lan ^{[1
,2
,3
]}

Wang, Xu-An ^{[1
,2
,3
]}

Jin, Yun-Peng ^{[1
,2
,3
]}

Zhang, Yi-Jian ^{[1
,2
,3
]}

Lu, Wei ^{[1
,2
,3
]}

Wu, Wen-Guang ^{[1
,2
,3
]}

Shu, Yi-Jun ^{[1
,2
,3
]}

Weng, Hao ^{[1
,2
,3
]}

Cao, Yang ^{[1
,2
,3
]}

Bao, Run-Fa ^{[1
,2
,3
]}

Liang, Hai-Bin ^{[1
,2
,3
]}

Wang, Zheng ^{[1
,2
,3
]}

Zhang, Yi-Chi ^{[1
,2
,3
]}

Gong, Wei ^{[1
,2
,3
]}

Zheng, Lei ^{[5
]}

Sun, Shu-Han ^{[4
]}

Liu, Ying-Bin ^{[1
,2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Gen Surg, Shanghai, Peoples R China

[2] Shanghai Res Ctr Biliary Tract Dis, Shanghai, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Inst Biliary Tract Dis, Shanghai, Peoples R China

[4] Second Mil Med Univ, Dept Med Genet, Shanghai, Peoples R China

[5] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

来源：

EMBO REPORTS | 2017年 / 18卷 / 10期

基金：

中国国家自然科学基金;

关键词：

ceRNA; gallbladder cancer; lncRNA; PAGBC; prognosis; LONG NONCODING RNA; CANCER-CELLS; METASTASIS; EXPRESSION; PROLIFERATION; LINC01133; DIFFERENTIATION; REPRESSION; BINDING; HULC;

D O I：

10.15252/embr.201744147

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long noncoding RNAs (lncRNAs) play roles in the development and progression of many cancers; however, the contributions of lncRNAs to human gallbladder cancer (GBC) remain largely unknown. In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosis-associated gallbladder cancer lncRNA (lncRNA-PAGBC), which we find to be an independent prognostic marker in GBC. Functional analysis indicates that lncRNA-PAGBC promotes tumour growth and metastasis of GBC cells. More importantly, as a competitive endogenous RNA (ceRNA), lncRNA-PAGBC competitively binds to the tumour suppressive microRNAs miR-133b and miR-511. This competitive role of lncRNA-PAGBC is required for its ability to promote tumour growth and metastasis and to activate the AKT/mTOR pathway. Moreover, lncRNA-PAGBC interacts with polyadenylate binding protein cytoplasmic 1 (PABPC1) and is stabilized by this interaction. This work provides novel insight on the molecular pathogenesis of GBC.

引用

页码：1837 / 1853

页数：17

共 46 条

[21] A Cytoplasmic NF-κB Interacting Long Noncoding RNA Blocks IκB Phosphorylation and Suppresses Breast Cancer Metastasis
Liu, Bodu
Sun, Lijuan
Liu, Qiang
Gong, Chang
Yao, Yandan
Lv, Xiaobin
Lin, Ling
Yao, Herui
Su, Fengxi
Li, Dangsheng
Zeng, Musheng
Song, Erwei
[J]. CANCER CELL, 2015, 27 (03) : 370 - 381
[22] The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer
Mabuchi, Seiji
Kuroda, Hiromasa
Takahashi, Ryoko
Sasano, Tomoyuki
[J]. GYNECOLOGIC ONCOLOGY, 2015, 137 (01) : 173 - 179
[23] Poly(A)-binding proteins: multifunctional scaffolds for the post-transcriptional control of gene expression
Mangus, DA
Evans, MC
Jacobson, A
[J]. GENOME BIOLOGY, 2003, 4 (07)
[24] Stability of a Long Noncoding Viral RNA Depends on a 9-nt Core Element at the RNA 5′ End to Interact with Viral ORF57 and Cellular PABPC1
Massimelli, Maria J.
Kang, Jeong-Gu
Majerciak, Vladimir
Le, Shu-Yun
Liewehr, David J.
Steinberg, Seth M.
Zheng, Zhi-Ming
[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2011, 7 (08): : 1145 - 1160
[25] Human Gene Coexpression Landscape: Confident Network Derived from Tissue Transcriptomic Profiles
Prieto, Carlos
Risueno, Alberto
Fontanillo, Celia
De Las Rivas, Javier
[J]. PLOS ONE, 2008, 3 (12):
[26] Network modeling links breast cancer susceptibility and centrosome dysfunction
Pujana, Miguel Angel
Han, Jing-Dong J.
Starita, Lea M.
Stevens, Kristen N.
Tewari, Muneesh
Ahn, Jin Sook
Rennert, Gad
Moreno, Victor
Kirchhoff, Tomas
Gold, Bert
Assmann, Volker
ElShamy, Wael M.
Rual, Jean-Francois
Levine, Douglas
Rozek, Laura S.
Gelman, Rebecca S.
Gunsalus, Kristin C.
Greenberg, Roger A.
Sobhian, Bijan
Bertin, Nicolas
Venkatesan, Kavitha
Ayivi-Guedehoussou, Nono
Sole, Xavier
Hernandez, Pilar
Lazaro, Conxi
Nathanson, Katherine L.
Weber, Barbara L.
Cusick, Michael E.
Hill, David E.
Offit, Kenneth
Livingston, David M.
Gruber, Stephen B.
Parvin, Jeffrey D.
Vidal, Marc
[J]. NATURE GENETICS, 2007, 39 (11) : 1338 - 1349
[27] SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia
Ramezani-Rad, Parham
Geng, Huimin
Hurtz, Christian
Chan, Lai N.
Chen, Zhengshan
Jumaa, Hassan
Melnick, Ari
Paietta, Elisabeth
Carroll, William L.
Willman, Cheryl L.
Lefebvre, Veronique
Mueschen, Markus
[J]. BLOOD, 2013, 121 (01) : 148 - 155
[28] The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells during Carcinogenesis
Riesco-Eizaguirre, Garcilaso
Wert-Lamas, Leon
Perales-Paton, Javier
Sastre-Perona, Ana
Fernandez, Lara P.
Santisteban, Pilar
[J]. CANCER RESEARCH, 2015, 75 (19) : 4119 - 4130
[29] A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
Salmena, Leonardo
Poliseno, Laura
Tay, Yvonne
Kats, Lev
Pandolfi, Pier Paolo
[J]. CELL, 2011, 146 (03) : 353 - 358
[30] PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth
Sharma, Narinder
Nanta, Rajesh
Sharma, Jay
Gunewardena, Sumedha
Singh, Karan P.
Shankar, Sharmila
Srivastava, Rakesh K.
[J]. ONCOTARGET, 2015, 6 (31) : 32039 - 32060

← 1 2 3 4 5 →