LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis

被引：199

作者：

Wu, Xiang-Song ^{[1
,2
,3
]}

Wang, Fang ^{[4
]}

Li, Huai-Feng ^{[1
,2
,3
]}

Hu, Yun-Ping ^{[1
,2
,3
]}

Jiang, Lin ^{[1
,2
,3
]}

Zhang, Fei ^{[1
,2
,3
]}

Li, Mao-Lan ^{[1
,2
,3
]}

Wang, Xu-An ^{[1
,2
,3
]}

Jin, Yun-Peng ^{[1
,2
,3
]}

Zhang, Yi-Jian ^{[1
,2
,3
]}

Lu, Wei ^{[1
,2
,3
]}

Wu, Wen-Guang ^{[1
,2
,3
]}

Shu, Yi-Jun ^{[1
,2
,3
]}

Weng, Hao ^{[1
,2
,3
]}

Cao, Yang ^{[1
,2
,3
]}

Bao, Run-Fa ^{[1
,2
,3
]}

Liang, Hai-Bin ^{[1
,2
,3
]}

Wang, Zheng ^{[1
,2
,3
]}

Zhang, Yi-Chi ^{[1
,2
,3
]}

Gong, Wei ^{[1
,2
,3
]}

Zheng, Lei ^{[5
]}

Sun, Shu-Han ^{[4
]}

Liu, Ying-Bin ^{[1
,2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Gen Surg, Shanghai, Peoples R China

[2] Shanghai Res Ctr Biliary Tract Dis, Shanghai, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Inst Biliary Tract Dis, Shanghai, Peoples R China

[4] Second Mil Med Univ, Dept Med Genet, Shanghai, Peoples R China

[5] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

来源：

EMBO REPORTS | 2017年 / 18卷 / 10期

基金：

中国国家自然科学基金;

关键词：

ceRNA; gallbladder cancer; lncRNA; PAGBC; prognosis; LONG NONCODING RNA; CANCER-CELLS; METASTASIS; EXPRESSION; PROLIFERATION; LINC01133; DIFFERENTIATION; REPRESSION; BINDING; HULC;

D O I：

10.15252/embr.201744147

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long noncoding RNAs (lncRNAs) play roles in the development and progression of many cancers; however, the contributions of lncRNAs to human gallbladder cancer (GBC) remain largely unknown. In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosis-associated gallbladder cancer lncRNA (lncRNA-PAGBC), which we find to be an independent prognostic marker in GBC. Functional analysis indicates that lncRNA-PAGBC promotes tumour growth and metastasis of GBC cells. More importantly, as a competitive endogenous RNA (ceRNA), lncRNA-PAGBC competitively binds to the tumour suppressive microRNAs miR-133b and miR-511. This competitive role of lncRNA-PAGBC is required for its ability to promote tumour growth and metastasis and to activate the AKT/mTOR pathway. Moreover, lncRNA-PAGBC interacts with polyadenylate binding protein cytoplasmic 1 (PABPC1) and is stabilized by this interaction. This work provides novel insight on the molecular pathogenesis of GBC.

引用

页码：1837 / 1853

页数：17

共 46 条

[1] [Anonymous], ONCOL RES
[2] Network biology:: Understanding the cell's functional organization
Barabási, AL
Oltvai, ZN
[J]. NATURE REVIEWS GENETICS, 2004, 5 (02) : 101 - U15
[3] Gallbladder cancer in India: A dismal picture
Batra, Y
Pal, S
Dutta, U
Desai, P
Garg, PK
Makharia, G
Ahuja, V
Pande, GK
Sahni, P
Chattopadhyay, TK
Tandon, RK
[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2005, 20 (02) : 309 - 314
[4] Gallbladder Cancer: Differences in Presentation, Surgical Treatment, and Survival in Patients Treated at Centers in Three Countries
Butte, Jean M.
Matsuo, Kenichi
Goenen, Mithat
D'Angelica, Michael I.
Waugh, Enrique
Allen, Peter J.
Fong, Yuman
DeMatteo, Ronald P.
Blumgart, Leslie
Endo, Itaru
De La Fuente, Hernan
Jarnagin, William R.
[J]. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2011, 212 (01) : 50 - 61
[5] MiR-511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3
Cao, Gang
Dong, Weihua
Meng, Xiaoxi
Liu, Hongchao
Liao, Huaqiang
Liu, Shiyuan
[J]. TUMOR BIOLOGY, 2015, 36 (06) : 4453 - 4459
[6] The Noncoding RNA Revolution-Trashing Old Rules to Forge New Ones
Cech, Thomas R.
Steitz, Joan A.
[J]. CELL, 2014, 157 (01) : 77 - 94
[7] A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA
Cesana, Marcella
Cacchiarelli, Davide
Legnini, Ivano
Santini, Tiziana
Sthandier, Olga
Chinappi, Mauro
Tramontano, Anna
Bozzoni, Irene
[J]. CELL, 2011, 147 (02) : 358 - 369
[8] Cluster analysis and display of genome-wide expression patterns
Eisen, MB
Spellman, PT
Brown, PO
Botstein, D
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) : 14863 - 14868
[9] The interaction of cytoplasmic poly(A)-binding protein with eukaryotic initiation factor 4G suppresses nonsense-mediated mRNA decay
Fatscher, Tobias
Boehm, Volker
Weiche, Benjamin
Gehring, Niels H.
[J]. RNA, 2014, 20 (10) : 1579 - 1592
[10] RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts
Geisler, Sarah
Coller, Jeff
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2013, 14 (11) : 699 - 712

← 1 2 3 4 5 →