13Check_RNA: a tool to evaluate 13C chemical shift assignments of RNA

被引:2
|
作者
Icazatti, A. A. [1 ]
Martin, O. A. [1 ]
Villegas, M. [1 ]
Szleifer, I [2 ,3 ,4 ]
Vila, J. A. [1 ]
机构
[1] Univ Nacl San Luis, Inst Matemat Aplicada San Luis, CONICET, RA-5700 San Luis, Argentina
[2] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA
[3] Northwestern Univ, Chem Life Proc Inst, Evanston, IL 60208 USA
[4] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA
关键词
H-1; PREDICTION; DATABASE;
D O I
10.1093/bioinformatics/bty470
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Motivation: Chemical shifts (CS) are an important source of structural information of macromolecules such as RNA. In addition to the scarce availability of CS for RNA, the observed values are prone to errors due to a wrong re-calibration or miss assignments. Different groups have dedicated their efforts to correct CS systematic errors on RNA. Despite this, there are not automated and freely available algorithms for evaluating the referencing of RNA C-13 CS before their deposition to the BMRB or re-reference already deposited CS with systematic errors. Results: Based on an existent method we have implemented an open source python module to correct C-13 CS (from here on C-13(exp)) systematic errors of RNAs and then return the results in 3 formats including the nmrstar one.
引用
收藏
页码:4124 / 4126
页数:3
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