Adenosine A2A agonist CGS 21680 decreases the affinity of dopamine D2 receptors for dopamine in human striatum

被引：0
作者：
Díaz-Cabiale, Z
Hurd, Y
Guidolin, D
Finnman, UB
Zoli, M
Agnati, LF
Vanderhaeghen, JJ
Fuxe, K
Ferré, S
机构：
[1] NIDA, Behav Neurosci Branch, NIH, Intramural Res Program, Baltimore, MD 21224 USA
[2] Karolinska Inst, Dept Neurosci, Stockholm, Sweden
[3] Karolinska Hosp, Dept Clin Neurosci, S-10401 Stockholm, Sweden
[4] Univ Modena & Reggio Emilia, Dept Biomed Sci, Physiol Sect, Modena, Italy
[5] Free Univ Brussels, Fac Med, Neurophysiol Lab, Brussels, Belgium
来源：
NEUROREPORT | 2001年 / 12卷 / 09期
关键词：
A2A receptor; adenosine; D2; receptor; dopamine; human; striatum;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Adenosine A2A receptors (A2AR) and dopamine D2 receptors (D2R) are highly concentrated in the striatum, where they are co-localized and exert reciprocal antagonistic interactions. It has been suggested that the A2R/D2R interactions might provide a therapeutic approach for basal ganglia disorders, such as Parkinson's disease, and schizophrenia. In the present work evidence is presented for the existence of an A2AR/D2R interaction in human brain by using quantitative autoradiography. The areas analyzed were the dorsal caudate nucleus and putamen. Parallel studies were performed in rat striatal sections. The A2AR agonist CGS 21680 was found to significantly increase IC50 values of competitive inhibition curves of the D2R/D3R antagonist [I-125]iodosulpiride vs dopamine both in rat striatal and human striatal brain sections. NeuroReport 12:1831-1834 (C) 2001 Lippincott Williams & Wilkins.
引用
收藏
页码：1831 / 1834
页数：4
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