Modified multicomponent Biginelli-Atwal reaction towards a straightforward construction of 5,6-dihydropyrimidin-4-ones

被引：13
作者：
Pair, Etienne
Levacher, Vincent
Briere, Jean-Francois [1 ]
机构：
[1] Normandie Univ, COBRA, UMR 6014, F-76821 Mont St Aignan, France
来源：
RSC ADVANCES | 2015年 / 5卷 / 57期
关键词：
CALCIUM-CHANNEL BLOCKERS; MELDRUMS ACID; SOLID-PHASE; BUILDING-BLOCKS; ACCESS; ESTERS; DIHYDROPYRIMIDONES; GENERATION; INHIBITORS; ROUTE;
D O I：
10.1039/c5ra08792a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A straightforward access to 5,6-dihydropyrimidin-4-ones as racemic mixtures or enantiopure diastereoisomers was achieved thanks to a multicomponent Knoevenagel-aza-Michael-Cyclocondensation reaction involving Meldrum's acid and isourea derivatives. This constitutes not only a novel MCR of the original Biginelli-Atwal condensation but allows the construction of dihydrouracyl derivatives known as biorelevant diazole architectures.
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收藏
页码：46267 / 46271
页数：5
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