Making Flavone Thioethers Using Halides and Powdered Sulfur or Na2S2O3

被引：26

作者：

Tang, Qiujie ^{[1
]}

Bian, Zhaogang ^{[1
]}

Wu, Wei ^{[1
]}

Wang, Jin ^{[1
]}

Xie, Ping ^{[2
]}

Pittman, Charles U., Jr. ^{[3
]}

Zhou, Aihua ^{[1
]}

机构：

[1] Jiangsu Univ, Pharm Sch, Xuefu Rd 301, Zhenjiang City 212013, Jiangsu, Peoples R China

[2] Jiangsu Univ Lib, Sci Informat Res Inst, Xuefu Rd 301, Zhenjiang City 212013, Jiangsu, Peoples R China

[3] Mississippi State Univ, Mississippi State, MS 39762 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 19期

关键词：

C-H FUNCTIONALIZATION; METAL-FREE CONDITIONS; S BOND FORMATION; ENANTIOSELECTIVE SULFENYLATION; ARYLSULFONYL CHLORIDES; DIARYL CHALCOGENIDES; CATALYZED SYNTHESIS; AMMONIUM IODIDE; DERIVATIVES; THIOLATION;

D O I：

10.1021/acs.joc.7b01320

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The method for constructing C-S bonds is very important in organic synthesis. Here a new sulfenylation method to generate flavone thioether derivatives was developed by employing aromatic or alkyl halides, S powder and Na2S2O3 as reactants. Good yields of regioselective C-alkyl-S and C-aryl S-substituted flavones were generated under relatively environmentally friendly and simple conditions. This method might be potentially applicable to large scale production, and it enriches current sulfenylation methods.

引用

页码：10617 / 10622

页数：6

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