Structural Plasticity Allows UCH37 to Be Primed by RPN13 or Locked Down by INO80G

被引:24
作者
Chen, Xiang [1 ]
Walters, Kylie J. [1 ]
机构
[1] NCI, Prot Proc Sect, Struct Biophys Lab, Ctr Canc Res, Ft Detrick, MD 21702 USA
关键词
PROTEASOME; UBIQUITIN; SPECIFICITY; ACTIVATION; MECHANISM; THERAPY; CANCER; DOMAIN;
D O I
10.1016/j.molcel.2015.02.025
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:767 / 768
页数:2
相关论文
共 11 条
  • [1] A bis-Benzylidine Piperidone Targeting Proteasome Ubiquitin Receptor RPN13/ADRM1 as a Therapy for Cancer
    Anchoori, Ravi K.
    Karanam, Balasubramanyam
    Peng, Shiwen
    Wang, Joshua W.
    Jiang, Rosie
    Tanno, Toshihiko
    Orlowski, Robert Z.
    Matsui, William
    Zhao, Ming
    Rudek, Michelle A.
    Hung, Chien-fu
    Chen, Xiang
    Walters, Kylie J.
    Roden, Richard B. S.
    [J]. CANCER CELL, 2013, 24 (06) : 791 - 805
  • [2] Structure of Proteasome Ubiquitin Receptor hRpn13 and Its Activation by the Scaffolding Protein hRpn2
    Chen, Xiang
    Lee, Byung-Hoon
    Finley, Daniel
    Walters, Kylie J.
    [J]. MOLECULAR CELL, 2010, 38 (03) : 404 - 415
  • [3] Inhibition of proteasome deubiquitinating activity as a new cancer therapy
    D'Arcy, Padraig
    Brnjic, Slavica
    Olofsson, Maria Hagg
    Fryknas, Marten
    Lindsten, Kristina
    De Cesare, Michelandrea
    Perego, Paola
    Sadeghi, Behnam
    Hassan, Moustapha
    Larsson, Rolf
    Linder, Stig
    [J]. NATURE MEDICINE, 2011, 17 (12) : 1636 - U150
  • [4] Mechanism of the Rpn13-induced activation of Uch37
    Jiao, Lianying
    Ouyang, Songying
    Shaw, Neil
    Song, Gaojie
    Feng, Yingang
    Niu, Fengfeng
    Qiu, Weicheng
    Zhu, Hongtao
    Hung, Li-Wei
    Zuo, Xiaobing
    Shtykova, V. Eleonora
    Zhu, Ping
    Dong, Yu-Hui
    Xu, Ruxiang
    Liu, Zhi-Jie
    [J]. PROTEIN & CELL, 2014, 5 (08) : 616 - 630
  • [5] Lam Y.A., 1997, BIOCHEMISTRY-US, V52, P3564
  • [6] Stabilization of an Unusual Salt Bridge in Ubiquitin by the Extra C-Terminal Domain of the Proteasome-Associated Deubiquitinase UCH37 as a Mechanism of Its Exo Specificity
    Morrow, Marie E.
    Kim, Myung-Il
    Ronau, Judith A.
    Sheedlo, Michael J.
    White, Rhiannon R.
    Chaney, Joseph
    Paul, Lake N.
    Lill, Markus A.
    Artavanis-Tsakonas, Katerina
    Das, Chittaranjan
    [J]. BIOCHEMISTRY, 2013, 52 (20) : 3564 - 3578
  • [7] Mechanism of UCH-L5 Activation and Inhibition by DEUBAD Domains in RPN13 and INO80G
    Sahtoe, Danny D.
    van Dijk, Willem J.
    El Oualid, Farid
    Ekkebus, Reggy
    Ovaa, Huib
    Sixma, Titia K.
    [J]. MOLECULAR CELL, 2015, 57 (05) : 887 - 900
  • [8] A common ancestry for BAP1 and Uch37 regulators
    Sanchez-Pulido, Luis
    Kong, Lesheng
    Ponting, Chris P.
    [J]. BIOINFORMATICS, 2012, 28 (15) : 1953 - 1956
  • [9] Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction
    Schreiner, Patrick
    Chen, Xiang
    Husnjak, Koraljka
    Randles, Leah
    Zhang, Naixia
    Elsasser, Suzanne
    Finley, Daniel
    Dikic, Ivan
    Walters, Kylie J.
    Groll, Michael
    [J]. NATURE, 2008, 453 (7194) : 548 - 552
  • [10] Structural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase
    VanderLinden, Ryan T.
    Hemmis, Casey W.
    Schmitt, Benjamin
    Ndoja, Ada
    Whitby, Frank G.
    Robinson, Howard
    Cohen, Robert E.
    Yao, Tingting
    Hill, Christopher P.
    [J]. MOLECULAR CELL, 2015, 57 (05) : 901 - 911