Oxidative stress induced by gibberellic acid in bone of suckling rats

被引：9
作者：
Troudi, Afef [1 ]
Ben Amara, Ibtissem [1 ]
Soudani, Nejla [1 ]
Bouaziz, Hanen [1 ]
Boudawara, Tahia [2 ]
Zeghal, Najiba [1 ]
机构：
[1] Univ Sfax, Physiol Anim Lab, Dept Life Sci, Sfax Fac Sci, Sfax 3000, Tunisia
[2] Univ Sfax, Anatomopathol Lab, CHU Habib Bourguiba, Sfax 3029, Tunisia
来源：
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2011年 / 74卷 / 04期
关键词：
GA(3); Suckling pups; Bone; Enzymatic and non-enzymatic antioxidants; Lipid peroxidation; Histological changes; OSTEOBLASTIC DIFFERENTIATION; ANTIOXIDANT DEFENSE; LIPID-PEROXIDATION; GLUTATHIONE; METABOLISM; TISSUES; ASSAYS; LIVER; MICE;
D O I：
10.1016/j.ecoenv.2010.10.010
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The present study investigates the bone maturity of suckling rats whose mothers were treated with gibberellic acid (GA(3)). Female Wistar rats were divided into two groups: group I that served as controls and group II that received orally GA(3) (200 ppm) from the 14th day of pregnancy until day 14 after delivery. In the GA(3) group, an increase in body and femur weights as well as in femur length of pups was noted when compared to controls. Lipid peroxidation was demonstrated by high femur malondialdehyde levels, while superoxide dismutase, catalase, glutathione peroxidase activities, glutathione and vitamin C levels in femur decreased. GA(3) caused a decrease in calcium and phosphorus levels in bone. The calcium concentration in plasma increased and the phosphorus concentration decreased, while urinary levels of calcium decreased and those of phosphate increased. Moreover, plasma total tartrate-resistant acid phosphatase and total alkaline phosphatase increased. Bone disorders were confirmed by femur histological changes. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：643 / 649
页数：7
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