Head and neck sarcomas: clinical and histopathological presentation, treatment modalities, and outcomes

被引:29
|
作者
Stavrakas, M. [1 ]
Nixon, I. [1 ]
Andi, K. [1 ]
Oakley, R. [1 ]
Jeannon, J. P. [1 ]
Lyons, A. [2 ]
McGurk, M. [2 ]
Urbano, T. Guerrero [3 ]
Thavaraj, S. [4 ]
Simo, R. [1 ]
机构
[1] Guys & St Thomas NHS Fdn Trust, Dept Otorhinolaryngol Head & Neck Surg, London, England
[2] Guys & St Thomas NHS Fdn Trust, Dept Oral & Maxillofacial Surg, London, England
[3] Guys & St Thomas NHS Fdn Trust, Dept Clin Oncol, London, England
[4] Guys & St Thomas NHS Fdn Trust, Dept Oral & Head & Neck Pathol, London, England
关键词
Sarcoma; Head And Neck Cancer; Sarcoma Management; Kaposi Sarcoma; Osteosarcoma; Chondrosarcoma; SOFT-TISSUE SARCOMAS; ACTIVE ANTIRETROVIRAL THERAPY; KAPOSIS-SARCOMA; PROGNOSTIC-FACTORS; ADULT HEAD; MANAGEMENT; SURGERY; UPDATE; RADIOTHERAPY; EXPERIENCE;
D O I
10.1017/S0022215116008604
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Background: Sarcoma of the head and neck is a rare condition that poses significant challenges in management and often requires radical multimodality treatment. Objectives: This study aimed to analyse current clinical presentation, evaluation, management dilemmas and oncological outcomes. Methods: Computer records and case notes were analysed, and 39 patients were identified. Variables were compared using Pearson's chi-square test and the log-rank test, while survival outcomes were calculated using the Kaplan-Meier method. Results: The histopathological diagnosis was Kaposi sarcoma in 20.5 per cent of cases, chondrosarcoma in 15.3 per cent and osteosarcoma in 10.2 per cent. A range of other sarcomas were diagnosed in the remaining patients. The site of disease was most commonly sinonasal, followed by the oral cavity and larynx. Conclusion: Wide local excision with clear resection margins is essential to achieve local control and long-term survival. There is a need for cross-specialty collaboration in order to accrue the evidence which will be necessary to improve long-term outcomes.
引用
收藏
页码:850 / 859
页数:10
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