Head and neck sarcomas: clinical and histopathological presentation, treatment modalities, and outcomes
被引:29
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作者:
Stavrakas, M.
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机构:
Guys & St Thomas NHS Fdn Trust, Dept Otorhinolaryngol Head & Neck Surg, London, EnglandGuys & St Thomas NHS Fdn Trust, Dept Otorhinolaryngol Head & Neck Surg, London, England
Stavrakas, M.
[1
]
Nixon, I.
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机构:
Guys & St Thomas NHS Fdn Trust, Dept Otorhinolaryngol Head & Neck Surg, London, EnglandGuys & St Thomas NHS Fdn Trust, Dept Otorhinolaryngol Head & Neck Surg, London, England
Nixon, I.
[1
]
Andi, K.
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机构:
Guys & St Thomas NHS Fdn Trust, Dept Otorhinolaryngol Head & Neck Surg, London, EnglandGuys & St Thomas NHS Fdn Trust, Dept Otorhinolaryngol Head & Neck Surg, London, England
Andi, K.
[1
]
Oakley, R.
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h-index: 0
机构:
Guys & St Thomas NHS Fdn Trust, Dept Otorhinolaryngol Head & Neck Surg, London, EnglandGuys & St Thomas NHS Fdn Trust, Dept Otorhinolaryngol Head & Neck Surg, London, England
Oakley, R.
[1
]
Jeannon, J. P.
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机构:
Guys & St Thomas NHS Fdn Trust, Dept Otorhinolaryngol Head & Neck Surg, London, EnglandGuys & St Thomas NHS Fdn Trust, Dept Otorhinolaryngol Head & Neck Surg, London, England
Jeannon, J. P.
[1
]
Lyons, A.
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机构:
Guys & St Thomas NHS Fdn Trust, Dept Oral & Maxillofacial Surg, London, EnglandGuys & St Thomas NHS Fdn Trust, Dept Otorhinolaryngol Head & Neck Surg, London, England
Lyons, A.
[2
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McGurk, M.
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机构:
Guys & St Thomas NHS Fdn Trust, Dept Oral & Maxillofacial Surg, London, EnglandGuys & St Thomas NHS Fdn Trust, Dept Otorhinolaryngol Head & Neck Surg, London, England
McGurk, M.
[2
]
Urbano, T. Guerrero
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机构:
Guys & St Thomas NHS Fdn Trust, Dept Clin Oncol, London, EnglandGuys & St Thomas NHS Fdn Trust, Dept Otorhinolaryngol Head & Neck Surg, London, England
Urbano, T. Guerrero
[3
]
Thavaraj, S.
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机构:
Guys & St Thomas NHS Fdn Trust, Dept Oral & Head & Neck Pathol, London, EnglandGuys & St Thomas NHS Fdn Trust, Dept Otorhinolaryngol Head & Neck Surg, London, England
Thavaraj, S.
[4
]
Simo, R.
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Guys & St Thomas NHS Fdn Trust, Dept Otorhinolaryngol Head & Neck Surg, London, EnglandGuys & St Thomas NHS Fdn Trust, Dept Otorhinolaryngol Head & Neck Surg, London, England
Simo, R.
[1
]
机构:
[1] Guys & St Thomas NHS Fdn Trust, Dept Otorhinolaryngol Head & Neck Surg, London, England
[2] Guys & St Thomas NHS Fdn Trust, Dept Oral & Maxillofacial Surg, London, England
[3] Guys & St Thomas NHS Fdn Trust, Dept Clin Oncol, London, England
[4] Guys & St Thomas NHS Fdn Trust, Dept Oral & Head & Neck Pathol, London, England
Sarcoma;
Head And Neck Cancer;
Sarcoma Management;
Kaposi Sarcoma;
Osteosarcoma;
Chondrosarcoma;
SOFT-TISSUE SARCOMAS;
ACTIVE ANTIRETROVIRAL THERAPY;
KAPOSIS-SARCOMA;
PROGNOSTIC-FACTORS;
ADULT HEAD;
MANAGEMENT;
SURGERY;
UPDATE;
RADIOTHERAPY;
EXPERIENCE;
D O I:
10.1017/S0022215116008604
中图分类号:
R76 [耳鼻咽喉科学];
学科分类号:
100213 ;
摘要:
Background: Sarcoma of the head and neck is a rare condition that poses significant challenges in management and often requires radical multimodality treatment. Objectives: This study aimed to analyse current clinical presentation, evaluation, management dilemmas and oncological outcomes. Methods: Computer records and case notes were analysed, and 39 patients were identified. Variables were compared using Pearson's chi-square test and the log-rank test, while survival outcomes were calculated using the Kaplan-Meier method. Results: The histopathological diagnosis was Kaposi sarcoma in 20.5 per cent of cases, chondrosarcoma in 15.3 per cent and osteosarcoma in 10.2 per cent. A range of other sarcomas were diagnosed in the remaining patients. The site of disease was most commonly sinonasal, followed by the oral cavity and larynx. Conclusion: Wide local excision with clear resection margins is essential to achieve local control and long-term survival. There is a need for cross-specialty collaboration in order to accrue the evidence which will be necessary to improve long-term outcomes.
机构:
Sotiria Gen Hosp, Athens Med Sch, Dept Med 3, Oncol Unit, Athens 11527, GreeceSotiria Gen Hosp, Athens Med Sch, Dept Med 3, Oncol Unit, Athens 11527, Greece
Syrigos, Kostas N.
Karachalios, Dimitris
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h-index: 0
机构:
Sotiria Gen Hosp, Athens Med Sch, Dept Med 3, Oncol Unit, Athens 11527, GreeceSotiria Gen Hosp, Athens Med Sch, Dept Med 3, Oncol Unit, Athens 11527, Greece
Karachalios, Dimitris
Karapanagiotou, Eleni M.
论文数: 0引用数: 0
h-index: 0
机构:
Sotiria Gen Hosp, Athens Med Sch, Dept Med 3, Oncol Unit, Athens 11527, Greece
Royal Marsden Hosp, Head & Neck Unit, London SW3 6JJ, EnglandSotiria Gen Hosp, Athens Med Sch, Dept Med 3, Oncol Unit, Athens 11527, Greece
Karapanagiotou, Eleni M.
Nutting, Christopher M.
论文数: 0引用数: 0
h-index: 0
机构:
Royal Marsden Hosp, Head & Neck Unit, London SW3 6JJ, EnglandSotiria Gen Hosp, Athens Med Sch, Dept Med 3, Oncol Unit, Athens 11527, Greece
Nutting, Christopher M.
Manolopoulos, Leonidas
论文数: 0引用数: 0
h-index: 0
机构:
Hippokrate Gen Hosp, Athens Med Sch, ENT Dept, Athens 11527, GreeceSotiria Gen Hosp, Athens Med Sch, Dept Med 3, Oncol Unit, Athens 11527, Greece
Manolopoulos, Leonidas
Harrington, Kevin J.
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h-index: 0
机构:
Royal Marsden Hosp, Head & Neck Unit, London SW3 6JJ, EnglandSotiria Gen Hosp, Athens Med Sch, Dept Med 3, Oncol Unit, Athens 11527, Greece
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Head & Neck Surg, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Head & Neck Surg, Los Angeles, CA 90095 USA
Peng, Kevin A.
Grogan, Tristan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Head & Neck Surg, Los Angeles, CA 90095 USA
Grogan, Tristan
Wang, Marilene B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Head & Neck Surg, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Head & Neck Surg, Los Angeles, CA 90095 USA
机构:
Y CEORL HNS, Young Confederat European ORL HNS, Vienna, Austria
Univ Florence, Dept Expt & Clin Med, Florence, ItalyY CEORL HNS, Young Confederat European ORL HNS, Vienna, Austria
Mannelli, Giuditta
Bassani, Sara
论文数: 0引用数: 0
h-index: 0
机构:
Y CEORL HNS, Young Confederat European ORL HNS, Vienna, Austria
Univ Verona, Head & Neck Dept, Unit Otorhinolaryngol, Verona, ItalyY CEORL HNS, Young Confederat European ORL HNS, Vienna, Austria
Bassani, Sara
Cosi, Ginevra
论文数: 0引用数: 0
h-index: 0
机构:
Y CEORL HNS, Young Confederat European ORL HNS, Vienna, Austria
Univ Florence, Dept Expt & Clin Med, Florence, ItalyY CEORL HNS, Young Confederat European ORL HNS, Vienna, Austria
Cosi, Ginevra
Fermi, Matteo
论文数: 0引用数: 0
h-index: 0
机构:
Y CEORL HNS, Young Confederat European ORL HNS, Vienna, Austria
IRCCS Azienda Osped Univ Bologna, Otolaryngol & Audiol Unit, Bologna, Italy
Alma Mater Studiorum Univ Bologna, Dept Med & Surg Sci, Bologna, ItalyY CEORL HNS, Young Confederat European ORL HNS, Vienna, Austria
Fermi, Matteo
Gazzini, Luca
论文数: 0引用数: 0
h-index: 0
机构:
Y CEORL HNS, Young Confederat European ORL HNS, Vienna, Austria
Paracelsus Med Private Univ PMU, Hosp Bolzano SABES ASDAA, Dept Otolaryngol Head & Neck Surg, Teaching Hosp, Bolzano, ItalyY CEORL HNS, Young Confederat European ORL HNS, Vienna, Austria
Gazzini, Luca
Liberale, Carlotta
论文数: 0引用数: 0
h-index: 0
机构:
Y CEORL HNS, Young Confederat European ORL HNS, Vienna, Austria
Univ Verona, Head & Neck Dept, Unit Otorhinolaryngol, Verona, ItalyY CEORL HNS, Young Confederat European ORL HNS, Vienna, Austria
Liberale, Carlotta
Mazzetti, Luca
论文数: 0引用数: 0
h-index: 0
机构:
Y CEORL HNS, Young Confederat European ORL HNS, Vienna, Austria
Univ Florence, Dept Expt & Clin Med, Florence, ItalyY CEORL HNS, Young Confederat European ORL HNS, Vienna, Austria
Mazzetti, Luca
Parrinello, Giampiero
论文数: 0引用数: 0
h-index: 0
机构:
Y CEORL HNS, Young Confederat European ORL HNS, Vienna, Austria
IRCCS San Martino Polyclin Hosp, Dept Otolaryngol Head & Neck Surg, Genoa, ItalyY CEORL HNS, Young Confederat European ORL HNS, Vienna, Austria
Parrinello, Giampiero
Saibene, Alberto Maria
论文数: 0引用数: 0
h-index: 0
机构:
Y CEORL HNS, Young Confederat European ORL HNS, Vienna, Austria
Univ Milan, Santi Paolo & Carlo Hosp, Otolaryngol Dept, Dept Hlth Sci, Milan, ItalyY CEORL HNS, Young Confederat European ORL HNS, Vienna, Austria
Saibene, Alberto Maria
Molteni, Gabriele
论文数: 0引用数: 0
h-index: 0
机构:
Y CEORL HNS, Young Confederat European ORL HNS, Vienna, Austria
IRCCS Azienda Osped Univ Bologna, Otolaryngol & Audiol Unit, Bologna, Italy
Alma Mater Studiorum Univ Bologna, Dept Med & Surg Sci, Bologna, ItalyY CEORL HNS, Young Confederat European ORL HNS, Vienna, Austria
Molteni, Gabriele
Comini, Lara Valentina
论文数: 0引用数: 0
h-index: 0
机构:
Y CEORL HNS, Young Confederat European ORL HNS, Vienna, Austria
FPO IRCCS, Candiolo Canc Inst, Head & Neck Oncol, Str Prov,142 KM 3-95, I-10060 Candiolo, TO, ItalyY CEORL HNS, Young Confederat European ORL HNS, Vienna, Austria
机构:
Univ Washington, Sch Med, Seattle, WA 98109 USAUniv Washington, Sch Med, Seattle, WA 98109 USA
Chang, Amy E.
Chai, Xiaoyu
论文数: 0引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USAUniv Washington, Sch Med, Seattle, WA 98109 USA
Chai, Xiaoyu
Pollack, Seth M.
论文数: 0引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA
Univ Washington, Med Ctr, Dept Med, Seattle, WA 98109 USA
Seattle Canc Care Alliance, Seattle, WA USAUniv Washington, Sch Med, Seattle, WA 98109 USA
Pollack, Seth M.
Loggers, Elizabeth
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Med Ctr, Dept Med, Seattle, WA 98109 USA
Seattle Canc Care Alliance, Seattle, WA USAUniv Washington, Sch Med, Seattle, WA 98109 USA
Loggers, Elizabeth
Rodler, Eve
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Med Ctr, Dept Med, Seattle, WA 98109 USA
Seattle Canc Care Alliance, Seattle, WA USAUniv Washington, Sch Med, Seattle, WA 98109 USA
Rodler, Eve
Dillon, Jasjit
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Sch Med, Seattle, WA 98109 USAUniv Washington, Sch Med, Seattle, WA 98109 USA
Dillon, Jasjit
Parvathaneni, Upendra
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Med Ctr, Dept Radiat Oncol, Seattle, WA 98109 USAUniv Washington, Sch Med, Seattle, WA 98109 USA
Parvathaneni, Upendra
Moe, Kris S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Med Ctr, Dept Otolaryngol, Seattle, WA 98109 USAUniv Washington, Sch Med, Seattle, WA 98109 USA
Moe, Kris S.
Futran, Neal
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Med Ctr, Dept Otolaryngol, Seattle, WA 98109 USAUniv Washington, Sch Med, Seattle, WA 98109 USA
Futran, Neal
Jones, Robin L.
论文数: 0引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA
Univ Washington, Med Ctr, Dept Med, Seattle, WA 98109 USA
Seattle Canc Care Alliance, Seattle, WA USAUniv Washington, Sch Med, Seattle, WA 98109 USA