MicroRNA-449a acts as a tumor suppressor in human bladder cancer through the regulation of pocket proteins

被引：93
|
作者：
Chen, Hong [1 ]
Lin, Yi-Wei [1 ]
Mao, Ye-Qing [1 ]
Wu, Jian [1 ]
Liu, Yun-Fu [1 ]
Zheng, Xiang-Yi [1 ]
Xie, Li-Ping [1 ]
机构：
[1] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Urol, Hangzhou 310003, Zhejiang, Peoples R China
来源：
CANCER LETTERS | 2012年 / 320卷 / 01期
基金：
中国国家自然科学基金;
关键词：
miR-449a; Bladder cancer; Cell cycle; Pocket protein; Targeted therapy; CELL-PROLIFERATION; PHOSPHORYLATION; TARGETS; EXPRESSION; MIR-449A; P130; TRANSITION; ARREST; FAMILY; E2F1;
D O I：
10.1016/j.canlet.2012.01.027
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Frequent downregulation of microRNA-449a (miR-449a) was detected in 14 human bladder cancer tissues. The restoration of miR-449a inhibited cell growth and induced G1-phase arrest in T24 and 5637 human bladder cancer cells. CDK6 and CDC25a were downregulated after miR-449a treatment, resulting in the functional accumulation of the pocket proteins Rb and p130. The growth of 124 tumor xenografts was suppressed by exogenous miR-449a, and the nuclear proliferation antigen Ki-67 was downregulated in miR-449a-treated tumors. These results suggest a tumor-suppressive role for miR-449a in human bladder cancer. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：40 / 47
页数：8
相关论文
共 50 条
  • [41] MiR-126 Acts as a Tumor Suppressor in Pancreatic Cancer Cells via the Regulation of ADAM9
    Hamada, Shin
    Satoh, Kennichi
    Fujibuchi, Wataru
    Hirota, Morihisa
    Kanno, Atsushi
    Unno, Jun
    Masamune, Atsushi
    Kikuta, Kazuhiro
    Kume, Kiyoshi
    Shimosegawa, Tooru
    MOLECULAR CANCER RESEARCH, 2012, 10 (01) : 3 - 10
  • [42] MicroRNA 218 Acts as a Tumor Suppressor by Targeting Multiple Cancer Phenotype-associated Genes in Medulloblastoma
    Venkataraman, Sujatha
    Birks, Diane K.
    Balakrishnan, Ilango
    Alimova, Irina
    Harris, Peter S.
    Patel, Purvi R.
    Handler, Michael H.
    Dubuc, Adrian
    Taylor, Michael D.
    Foreman, Nicholas K.
    Vibhakar, Rajeev
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (03) : 1918 - 1928
  • [43] SHP-1 acts as a tumor suppressor by interacting with EGFR and predicts the prognosis of human breast cancer
    Geng, Qian
    Xian, Ruiting
    Yu, Yinjue
    Chen, Fengsheng
    Li, Rong
    CANCER BIOLOGY & MEDICINE, 2022, 19 (04) : 468 - 485
  • [44] miR-489 acts as a tumor suppressor in human gastric cancer by targeting PROX1
    Zhang, Bin
    Ji, Sheqing
    Ma, Fei
    Ma, Qi
    Lu, Xianzhi
    Chen, Xiaobing
    AMERICAN JOURNAL OF CANCER RESEARCH, 2016, 6 (09): : 2021 - 2030
  • [45] The tumor suppressor microRNA-223 targets WDR62 directly in bladder cancer
    Sugita, Satoshi
    Yoshino, Hirofumi
    Osako, Yoiti
    Sakaguchi, Takashi
    Miyamoto, Kazutaka
    Yonemori, Masaya
    Matushita, Ryosuke
    Enokida, Hideki
    Nakagawa, Masayuki
    CANCER SCIENCE, 2018, 109 : 302 - 302
  • [46] γ-Catenin acts as a tumor suppressor through context-dependent mechanisms in colorectal cancer
    Nagel, Jutta Maria
    Lahm, Harald
    Ofner, Andrea
    Goeke, Burkhard
    Kolligs, Frank Thomas
    INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2017, 32 (09) : 1243 - 1251
  • [47] MicroRNA-155 acts as a tumor suppressor in colorectal cancer by targeting CTHRC1 in vitro
    Liu, Jingtian
    Chen, Zongyou
    Xiang, Jianbin
    Gu, Xiaodong
    ONCOLOGY LETTERS, 2018, 15 (04) : 5561 - 5568
  • [48] miR-138-5p acts as a tumor suppressor by targeting hTERT in human colorectal cancer
    Wang, Xiaotao
    Zhao, Yongkui
    Cao, Wenbin
    Wang, Changyou
    Sun, Bingfu
    Chen, Jianli
    Li, Shuguang
    Chen, Junmao
    Cui, Mingxin
    Zhang, Bo
    Yang, Guanghua
    Liu, Yang
    Yu, Xiangyang
    Zhang, Guozhi
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2017, 10 (12): : 11516 - 11525
  • [49] Down-regulation of the ErbB3 binding protein 1 in human bladder cancer promotes tumor progression and cell proliferation
    He, Hui-chan
    Ling, Xiao-hui
    Zhu, Jian-guo
    Fu, Xin
    Han, Zhao-dong
    Liang, Yu-xian
    Deng, Ye-han
    Lin, Zhuo-yuan
    Chen, Guo
    Chen, Yan-fei
    Mo, Ru-jun
    Zhong, Wei-de
    MOLECULAR BIOLOGY REPORTS, 2013, 40 (05) : 3799 - 3805
  • [50] Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer
    Escudero-Esparza, Astrid
    Bartoschek, Michael
    Gialeli, Chrysostomi
    Okroj, Marcin
    Owen, Sioned
    Jirstrom, Karin
    Orimo, Akira
    Jiang, Wen G.
    Pietras, Kristian
    Blom, Anna M.
    ONCOTARGET, 2016, 7 (47) : 76920 - 76933
12345