MicroRNA-449a acts as a tumor suppressor in human bladder cancer through the regulation of pocket proteins

被引：93

作者：

Chen, Hong ^{[1
]}

Lin, Yi-Wei ^{[1
]}

Mao, Ye-Qing ^{[1
]}

Wu, Jian ^{[1
]}

Liu, Yun-Fu ^{[1
]}

Zheng, Xiang-Yi ^{[1
]}

Xie, Li-Ping ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Urol, Hangzhou 310003, Zhejiang, Peoples R China

来源：

CANCER LETTERS | 2012年 / 320卷 / 01期

基金：

中国国家自然科学基金;

关键词：

miR-449a; Bladder cancer; Cell cycle; Pocket protein; Targeted therapy; CELL-PROLIFERATION; PHOSPHORYLATION; TARGETS; EXPRESSION; MIR-449A; P130; TRANSITION; ARREST; FAMILY; E2F1;

D O I：

10.1016/j.canlet.2012.01.027

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Frequent downregulation of microRNA-449a (miR-449a) was detected in 14 human bladder cancer tissues. The restoration of miR-449a inhibited cell growth and induced G1-phase arrest in T24 and 5637 human bladder cancer cells. CDK6 and CDC25a were downregulated after miR-449a treatment, resulting in the functional accumulation of the pocket proteins Rb and p130. The growth of 124 tumor xenografts was suppressed by exogenous miR-449a, and the nuclear proliferation antigen Ki-67 was downregulated in miR-449a-treated tumors. These results suggest a tumor-suppressive role for miR-449a in human bladder cancer. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：40 / 47

页数：8

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