MicroRNA-449a acts as a tumor suppressor in human bladder cancer through the regulation of pocket proteins

被引：93
|
作者：
Chen, Hong [1 ]
Lin, Yi-Wei [1 ]
Mao, Ye-Qing [1 ]
Wu, Jian [1 ]
Liu, Yun-Fu [1 ]
Zheng, Xiang-Yi [1 ]
Xie, Li-Ping [1 ]
机构：
[1] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Urol, Hangzhou 310003, Zhejiang, Peoples R China
来源：
CANCER LETTERS | 2012年 / 320卷 / 01期
基金：
中国国家自然科学基金;
关键词：
miR-449a; Bladder cancer; Cell cycle; Pocket protein; Targeted therapy; CELL-PROLIFERATION; PHOSPHORYLATION; TARGETS; EXPRESSION; MIR-449A; P130; TRANSITION; ARREST; FAMILY; E2F1;
D O I：
10.1016/j.canlet.2012.01.027
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Frequent downregulation of microRNA-449a (miR-449a) was detected in 14 human bladder cancer tissues. The restoration of miR-449a inhibited cell growth and induced G1-phase arrest in T24 and 5637 human bladder cancer cells. CDK6 and CDC25a were downregulated after miR-449a treatment, resulting in the functional accumulation of the pocket proteins Rb and p130. The growth of 124 tumor xenografts was suppressed by exogenous miR-449a, and the nuclear proliferation antigen Ki-67 was downregulated in miR-449a-treated tumors. These results suggest a tumor-suppressive role for miR-449a in human bladder cancer. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：40 / 47
页数：8
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