共 50 条
Langerhans cells down-regulate inflammation-driven alveolar bone loss
被引:64
作者:
Arizon, Moran
[1
]
Nudel, Itay
[1
]
Segev, Hadas
[1
]
Mizraji, Gabriel
[1
]
Elnekave, Mazal
[1
]
Furmanov, Karina
[1
]
Eli-Berchoer, Luba
[1
]
Clausen, Bjorn E.
[3
]
Shapira, Lior
[2
]
Wilensky, Asaf
[2
]
Hovav, Avi-Hai
[1
]
机构:
[1] Hebrew Univ Jerusalem, Hadassah Sch Dent Med, Inst Dent Sci, IL-91120 Jerusalem, Israel
[2] Hebrew Univ Jerusalem, Hadassah Sch Dent Med, Dept Periodontol, IL-91120 Jerusalem, Israel
[3] Univ Med Ctr, Erasmus Med Ctr, Dept Immunol, NL-3015 GE Rotterdam, Netherlands
来源:
基金:
以色列科学基金会;
关键词:
osteoimmunology;
Porphyromonas gingivalis;
oral mucosa;
experimental periodontitis;
CD4(+) T-CELLS;
DERMAL DENDRITIC CELLS;
EXPERIMENTAL PERIODONTITIS;
RECEPTOR ACTIVATOR;
GAMMA-INTERFERON;
OSTEOPROTEGERIN LIGAND;
ORAL-MUCOSA;
IFN-GAMMA;
IN-VIVO;
MICE;
D O I:
10.1073/pnas.1116770109
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
Excessive bone resorption is frequently associated with chronic infections and inflammatory diseases. Whereas T cells were demonstrated to facilitate osteoclastogenesis in such diseases, the role of dendritic cells, the most potent activators of naive T cells, remains unclear. Using a model involving inflammation-driven alveolar bone loss attributable to infection, we showed that in vivo ablation of Langerhans cells (LCs) resulted in enhanced bone loss. An increased infiltration of B and T lymphocytes into the tissue surrounding the bone was observed in LC-ablated mice, including receptor activator of NF-kappa B ligand (RANKL)-expressing CD4(+) T cells with known capabilities of altering bone homeostasis. In addition, the absence of LCs significantly reduced the numbers of CD4(+)Foxp3(+) T-regulatory cells in the tissue. Further investigation revealed that LCs were not directly involved in presenting antigens to T cells. Nevertheless, despite their low numbers in the tissue, the absence of LCs resulted in an elevated activation of CD4(+) but not CD8(+) T cells. This activation involved elevated production of IFN-gamma but not IL-17 or IL-10 cytokines. Our data, thus, reveal a protective immunoregulatory role for LCs in inflammation-induced alveolar bone resorption, by inhibiting IFN-gamma secretion and excessive activation of RANKL(+)CD4(+) T cells with a capability of promoting osteoclastogenesis.
引用
收藏
页码:7043 / 7048
页数:6
相关论文