Synthesis and Antimicrobial Activity of New 2,5-Disubstituted 1,3,4-Oxadiazoles and 1,2,4-Triazoles and Their Sugar Derivatives

被引：22
|
作者：
El-Sayed, Wael A. [1 ,2 ]
Ali, Omar M. [3 ]
Hendy, Hend A. [3 ]
Abdel-Rahman, Adel A. H. [1 ,3 ]
机构：
[1] No Border Univ, Dept Chem, Ar Ar, Saudi Arabia
[2] Natl Res Ctr, Dept Photochem, Cairo, Egypt
[3] Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm, Egypt
来源：
CHINESE JOURNAL OF CHEMISTRY | 2012年 / 30卷 / 01期
关键词：
1; 3; 4-oxadiazoles; 2; 4-triazoles; sugar hydrazones; acyclic nucleosides; antimicrobial activity; C-FURYL GLYCOSIDES; ANTIVIRAL EVALUATION; ANTIPROLIFERATIVE ACTIVITY; IN-VITRO; TRIAZOLOTHIADIAZOLES; HETEROCYCLES; NUCLEOSIDES; ANALOGS; AGENTS;
D O I：
10.1002/cjoc.201100029
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of new 2,5-disubstituted-1,3,4-oxadiazole and 1,2,4-triazole derivatives were synthesized by heterocyclization of acid hydrazide 1 and thiosemicarbazide derivative 2. Furthermore, the acyclic C-nucleoside analogs were prepared by cyclization of their corresponding sugar hydrazones by reaction with acetic anhydride. The antimicrobial activity of the prepared compounds was evaluated and some of the synthesized compounds revealed good activities against fungi.
引用
收藏
页码：77 / 83
页数：7
相关论文
共 50 条
  • [31] Synthesis and Antimicrobial Activity of New Substituted 1,2,4-Triazoles and their Acyclic C-Nucleoside Analogues
    El-Sayed, Wael A.
    Ali, Omar M.
    El-Dakkony, Saly R.
    Abdel-Rahman, Adel A. -H.
    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, 2010, 65 (1-2): : 15 - 21
  • [32] Electrochemical Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles from α-Keto Acids and Acylhydrazines Under Mild Conditions
    Lu, Fangling
    Gong, Fengping
    Li, Liangsen
    Zhang, Kan
    Li, Zhen
    Zhang, Xinwei
    Yin, Ying
    Wang, Ying
    Gao, Ziwei
    Zhang, Heng
    Lei, Aiwen
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2020, 2020 (22) : 3257 - 3260
  • [33] A convenient synthesis of 4,5-disubstituted 1,2,4-triazoles functionalized in position 3
    Ivanova, NV
    Sviridov, SI
    Shorshnev, SV
    Stepanov, AE
    SYNTHESIS-STUTTGART, 2006, (01): : 156 - 160
  • [34] Synthesis of 3,5-disubstituted [1,2,4]-oxadiazoles
    Boral, Rajesh O.
    Farooqui, Mazahar
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2008, 85 (05) : 569 - 573
  • [35] Synthesis and antiviral evaluation of new 2,5-disubstituted 1,3,4-oxadiazole derivatives and their acyclic nucleoside analogues
    El-Sayed, Wael A.
    El-Essawy, Farag A.
    Ali, Omar M.
    Nasr, Barsis S.
    Abdalla, Mohamed M.
    Abdel-Rahman, Adel A. -H.
    MONATSHEFTE FUR CHEMIE, 2010, 141 (09): : 1021 - 1028
  • [36] A Safe Synthesis of 1,5-Disubstituted 3-Amino-1H-1,2,4-triazoles from 1,3,4-Oxadiazolium Hexafluorophosphates
    Wong, Brian
    Stumpf, Andreas
    Carrera, Diane
    Gu, Chunang
    Zhang, Haiming
    SYNTHESIS-STUTTGART, 2013, 45 (08): : 1083 - 1093
  • [37] Convenient preparation of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles promoted by Dess-Martin reagent
    Dobrota, Cristian
    Paraschivescu, Codruta C.
    Dumitru, Ioana
    Matache, Mihaela
    Baciu, Ion
    Ruta, Lavinia L.
    TETRAHEDRON LETTERS, 2009, 50 (17) : 1886 - 1888
  • [38] Synthesis of new derivatives of hydrazinecarbothioamides and 1,2,4-triazoles, and an evaluation of their antimicrobial activities
    Socea, Laura I.
    Saramet, Gabriel
    Draghici, Constantin
    Socea, Bogdan
    Constantin, Vlad D.
    Radu-Popescu, Manuela A.
    JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 2015, 80 (12) : 1461 - 1470
  • [39] Antimycobacterial and antimicrobial study of new 1,2,4-triazoles with benzothiazoles
    Patel, Navin B.
    Khan, Imran H.
    Rajani, Smita D.
    ARCHIV DER PHARMAZIE, 2010, 343 (11-12) : 692 - 699
  • [40] Synthesis and anticancer evaluation of new lipophilic 1,2,4 and 1,3,4-oxadiazoles
    Caneschi, Wiliam
    Enes, Karine Braga
    de Mendonca, Camille Carvalho
    Fernandes, Fabio de Souza
    Miguel, Fabio Balbino
    Martins, Jefferson da Silva
    Le Hyaric, Mireille
    Pinho, Roberto Rosas
    Duarte, Lucas Mattos
    Leal de Oliveira, Marcone Augusto
    Dos Santos, Hello F.
    Paz Lopes, Miriam Teresa
    Dittz, Dalton
    Silva, Heveline
    Costa Couri, Mara Rubia
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 165 : 18 - 30
12345