Synthesis and Antimicrobial Activity of New 2,5-Disubstituted 1,3,4-Oxadiazoles and 1,2,4-Triazoles and Their Sugar Derivatives

被引：24
作者：
El-Sayed, Wael A. [1 ,2 ]
Ali, Omar M. [3 ]
Hendy, Hend A. [3 ]
Abdel-Rahman, Adel A. H. [1 ,3 ]
机构：
[1] No Border Univ, Dept Chem, Ar Ar, Saudi Arabia
[2] Natl Res Ctr, Dept Photochem, Cairo, Egypt
[3] Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm, Egypt
来源：
CHINESE JOURNAL OF CHEMISTRY | 2012年 / 30卷 / 01期
关键词：
1; 3; 4-oxadiazoles; 2; 4-triazoles; sugar hydrazones; acyclic nucleosides; antimicrobial activity; C-FURYL GLYCOSIDES; ANTIVIRAL EVALUATION; ANTIPROLIFERATIVE ACTIVITY; IN-VITRO; TRIAZOLOTHIADIAZOLES; HETEROCYCLES; NUCLEOSIDES; ANALOGS; AGENTS;
D O I：
10.1002/cjoc.201100029
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of new 2,5-disubstituted-1,3,4-oxadiazole and 1,2,4-triazole derivatives were synthesized by heterocyclization of acid hydrazide 1 and thiosemicarbazide derivative 2. Furthermore, the acyclic C-nucleoside analogs were prepared by cyclization of their corresponding sugar hydrazones by reaction with acetic anhydride. The antimicrobial activity of the prepared compounds was evaluated and some of the synthesized compounds revealed good activities against fungi.
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页码：77 / 83
页数：7
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