Ozone and growth factors in the treatment of arthralgias secondary to vaccination against Covid-19. Case report

Background: The use of vaccines as preventive agents for SARS-CoV-2 infection has generated collateral effects, including arthralgias. The objective of this case report was to describe the treatment and evolution of a patient with arthralgia secondary to vaccination with BNT162b2 (Pfizer - BioNTech), with ozone and ozonized growth factors. Methods: The patient was a 53-year-old, white male with no medical history who had received 2 doses of the BNT162b2 vaccine, with an interval of 6 weeks. After the second dose, the patient reported the permanence of arthralgia in the fifth finger of the right hand, and the third finger of the left hand with an intensity of 9-10 on the visual analog scale (VAS) scale. The patient was locally infiltrated with ozone 6 mg/mL (intra articular and with the glove technique), twice a week for 2 weeks, and was subsequently treated with platelet-derived growth factor, Silfradent (R) CGF (Concentrated Grow Factors) activated with ozone, in a single session. Results: The patient evolved satisfactorily with a final VAS reduction to a value of 1-2 and reduction of clinical symptoms. Medical ozone and regenerative medicine using CGF, can represent a useful complement in mitigating collateral effects such as post-vaccination arthralgias. Conclusions: Larger clinical studies are needed to demonstrate its clinical efficacy in this indication.