Thiol redox control via thioredoxin and glutaredoxin systems

被引：340
|
作者：
Holmgren, A [1 ]
Johansson, C [1 ]
Berndt, C [1 ]
Lönn, ME [1 ]
Hudemann, C [1 ]
Lillig, CH [1 ]
机构：
[1] Karolinska Inst, Dept Med Biochem & Biophys, Med Nobel Inst Biochem, SE-17177 Stockholm, Sweden
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2005年 / 33卷
关键词：
disulphide; glutaredoxin (Grx); GSH; thiol redox control; thioredoxin (Trx); thioredoxin reductase (TrxR);
D O I：
10.1042/BST0331375
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms. Here, we give a brief overview of the human Trx and Grx systems. The main part focuses on our current knowledge about mitochondrial Grx2, which facilitates mitochondrial redox homoeostasis during oxidative stress-induced apoptosis.
引用
收藏
页码：1375 / 1377
页数：3
相关论文
共 50 条
  • [1] Thioredoxin and glutaredoxin systems in cellular thiol redox homeostasis
    Hashemy, Seyed Isaac
    Holmgren, Arne
    FREE RADICAL RESEARCH, 2007, 41 : S7 - S7
  • [2] Modulation of thiol-dependent redox system by metal ions via thioredoxin and glutaredoxin systems
    Ouyang, Yanfang
    Peng, Yi
    Li, Jing
    Holmgren, Arne
    Lu, Jun
    METALLOMICS, 2018, 10 (02) : 218 - 228
  • [3] Modulation of the redox state of tubulin by the thioredoxin and glutaredoxin reductase systems
    Landino, L
    Kennett, K
    Moynihan, K
    Alston, J
    FREE RADICAL BIOLOGY AND MEDICINE, 2003, 35 : S95 - S95
  • [4] Redox control of exocytosis:: regulatory role of NADPH, thioredoxin and glutaredoxin
    Schuit, FC
    Ivarsson, R
    Quintens, R
    Dejonghe, S
    Tsukamoto, K
    in't Veld, P
    Renström, E
    DIABETOLOGIA, 2005, 48 : A172 - A173
  • [5] Redox control of exocytosis -: Regulatory role of NADPH, thioredoxin, and glutaredoxin
    Ivarsson, R
    Quintens, R
    Dejonghe, S
    Tsukamoto, K
    Veld, P
    Renström, E
    Schuit, FC
    DIABETES, 2005, 54 (07) : 2132 - 2142
  • [6] THIOREDOXIN AND GLUTAREDOXIN SYSTEMS
    HOLMGREN, A
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1989, 264 (24) : 13963 - 13966
  • [7] Absolute gene expression patterns of thioredoxin and glutaredoxin redox systems in mouse
    Jurado, J
    Prieto-Alamo, MJ
    Madrid-Rísquez, J
    Pueyo, C
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (46) : 45546 - 45554
  • [8] Selenium and the thioredoxin and glutaredoxin systems
    Bjornstedt, M
    Kumar, S
    Bjorkhem, L
    Spyrou, G
    Holmgren, A
    BIOMEDICAL AND ENVIRONMENTAL SCIENCES, 1997, 10 (2-3) : 271 - 279
  • [9] Selenium and the Thioredoxin and Glutaredoxin Systems
    MIKAEL BJORNSTEDT
    SUSHIL KUMAR
    LINDA BJ■RKHEM
    GIANNIS SPYROU
    AND ARNE HOLMGREN(The Medical Nobel Institute for Biochemistry
    Department of Bioscience
    BiomedicalandEnvironmentalSciences, 1997, (Z1) : 271 - 279
  • [10] Enzymes or redox couples? The kinetics of thioredoxin and glutaredoxin reactions in a systems biology context
    Pillay, Che S.
    Hofmeyr, Jan-Hendrik S.
    Olivier, Brett G.
    Snoep, Jacky L.
    Rohwer, Johann M.
    BIOCHEMICAL JOURNAL, 2009, 417 : 269 - 275
12345