Drug Metabolism by Cytochrome P450 Enzymes: What Distinguishes the Pathways Leading to Substrate Hydroxylation Over Desaturation?

被引：3

作者：

Ji, Li

Faponle, Abayomi S.

Quesne, Matthew G.

Sainna, Mala A.

Zhang, Jing

Franke, Alicja

Kumar, Devesh

van Eldik, Rudi

Liu, Weiping

de Visser, Sam P.

机构：

[1] College of Environmental and Resource Sciences, Zhejiang University, Yuhangtang Road 866, Hangzhou

[2] Manchester Institute of Biotechnology, School of Chemical Engineering and Analytical Science, University of Manchester, 131 Princess Street, Manchester

[3] Inorganic Chemistry, Department of Chemistry and Pharmacy, University of Erlangen-Nuremberg, Egerlandstrasse 1, Erlangen

[4] Faculty of Chemistry, Jagiellonian University, Ingardena 3, Krakow

[5] Department of Applied Physics, School for Physical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Rai Bareilly Road, Lucknow

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2015年 / 21卷 / 25期

基金：

英国工程与自然科学研究理事会; 中国国家自然科学基金; 英国生物技术与生命科学研究理事会;

关键词：

compound I; density functional calculations; enzyme catalysis; oxygen atom transfer; reaction mechanisms;

D O I：

10.1002/chem.201501444

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Invited for the cover of this issue are the groups of SamP. deVisser at the University of Manchester and Weiping Liu from Zhejiang University and colleagues. The cover shows the competitive routes that can be taken to convert drug and other xenobiotic molecules in the body, and most importantly in the liver. Read the full text of the article at .10.1002/chem.201500329.

引用

页码：8973 / 8973

页数：1

共 92 条

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