Hyaluronic acid-conjugated mesoporous silica nanoparticles: excellent colloidal dispersity in physiological fluids and targeting efficacy

被引：81

作者：

Ma, Ming ^{[1
]}

Chen, Hangrong ^{[1
]}

Chen, Yu ^{[1
]}

Zhang, Kun ^{[1
]}

Wang, Xia ^{[1
]}

Cui, Xiangzhi ^{[1
]}

Shi, Jianlin ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2012年 / 22卷 / 12期

关键词：

IN-VIVO; CANCER;

D O I：

10.1039/c2jm15489g

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Hyaluronic acid-conjugated mesoporous silica nanoparticles (MSNs-HA) have been synthesized via a facile amidation reaction. This novel strategy can efficiently solve the agglomeration problem of MSNs in physiological fluids. The cellular experiments showed that MSNs-HA is capable of selectively targeting specific cancer cells over-expressing the CD44 protein, leading to rapid and concentration-dependent uptake by the cancer cells through the receptor-mediated endocytosis mechanism. In contrast, no selective targeting of MSNs-HA can be found to the CD44 low-expressing cells, such as MCF-7 and L929 cells. The hydrophobic camptothecin (CPT) drug was encapsulated into MSNs-HA, which showed enhanced cytotoxicity to the Hela cells compared to both free CPT and CPT-loaded MSNs-HA in the presence of excess free HA.

引用

页码：5615 / 5621

页数：7

共 33 条

[1] CD44 IS THE PRINCIPAL CELL-SURFACE RECEPTOR FOR HYALURONATE [J].