Three New Sesquiterpene Aryl Esters from the Mycelium of Armillaria mellea

被引：22

作者：

Chen, Chien-Chih ^{[1
,2
]}

Kuo, Yueh-Hsiung ^{[3
,4
]}

Cheng, Jing-Jy ^{[5
]}

Sung, Ping-Jyun ^{[6
,7
]}

Ni, Ching-Li ^{[1
]}

Chen, Chin-Chu ^{[8
]}

Shen, Chien-Chang ^{[5
]}

机构：

[1] HungKuang Univ, Dept Biotechnol, Taichung 433, Taiwan

[2] HungKuang Univ, Dept Nursing, Taichung 433, Taiwan

[3] China Med Univ, Dept Chinese Pharmaceut Sci & Chinese Med Resourc, Taichung 404, Taiwan

[4] Asia Univ, Dept Biotechnol, Taichung 413, Taiwan

[5] Minist Hlth & Welfare, Natl Res Inst Chinese Med, Taipei 112, Taiwan

[6] Natl Dong Hwa Univ, Grad Inst Marine Biol, Pingtung 944, Taiwan

[7] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[8] Grape King Bio Ltd, Ctr Biotechnol, Taoyuan 320, Taiwan

来源：

MOLECULES | 2015年 / 20卷 / 06期

关键词：

sesquiterpene aryl esters; Armillaria mellea; Tricholomataceae; cytotoxicity; MELLEOLIDE; CULTURE;

D O I：

10.3390/molecules20069994

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three new sesquiterpene aryl esters and eight known compounds were isolated from the EtOH extract of the mycelium of Armillaria mellea. The structures of new compounds were established by analysis of their spectroscopic data. Some of the isolates showed cytotoxicity to a variety of cancer cell lines, including MCF-7, H460, HT-29, and CEM.

引用

页码：9994 / 10003

页数：10

共 19 条

[1] SECONDARY MOLD METABOLITES .14. STRUCTURES OF MELLOLIDES-B-D, 3 ANTIBACTERIAL SESQUITERPENOIDS FROM ARMILLARIA-MELLEA [J].

ARNONE, A ;

CARDILLO, R ;

NASINI, G .

PHYTOCHEMISTRY, 1986, 25 (02) :471-474

[2] SECONDARY MOLD METABOLITES .19. STRUCTURE ELUCIDATION AND ABSOLUTE-CONFIGURATION OF MELLEDONAL-B AND MELLEDONAL-C, NOVEL ANTIBACTERIAL SESQUITERPENOIDS FROM ARMILLARIA-MELLEA - X-RAY MOLECULAR-STRUCTURE OF MELLEDONAL-C [J].

ARNONE, A ;

CARDILLO, R ;

NASINI, G ;

MEILLE, SV .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1988, (03) :503-510

[3] Cytotoxic and antifungal activities of melleolide antibiotics follow dissimilar structure-activity relationships [J].

Bohnert, Markus ;

Nuetzmann, Hans-Wilhelm ;

Schroeckh, Volker ;

Horn, Fabian ;

Dahse, Hans-Martin ;

Brakhage, Axel A. ;

Hoffmeister, Dirk .

PHYTOCHEMISTRY, 2014, 105 :101-108

[4] In vitro cytotoxicity of melleolide antibiotics: Structural and mechanistic aspects [J].

Bohnert, Markus ;

Miethbauer, Sebastian ;

Dahse, Hans-Martin ;

Ziemen, Johannes ;

Nett, Markus ;

Hoffmeister, Dirk .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (07) :2003-2006

[5] Armillaria mellea component armillarikin induces apoptosis in human leukemia cells [J].

Chen, Yu-Jen ;

Wu, Szu-Yuan ;

Chen, Chien-Chih ;

Tsao, Yu-Lin ;

Hsu, Nai-Chi ;

Chou, Yu-Chi ;

Huang, Huey-Lan .

JOURNAL OF FUNCTIONAL FOODS, 2014, 6 :196-204

[6] Therapeutic and Radiosensitizing Effects of Armillaridin on Human Esophageal Cancer Cells [J].

Chi, Chih-Wen ;

Chen, Chien-Chih ;

Chen, Yu-Jen .

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2013, 2013

[7] 2 NEW SESQUITERPENE ESTERS FROM ARMILLARIA-MELLEA [J].

DONNELLY, DMX ;

QUIGLEY, PF ;

COVENEY, DJ ;

POLONSKY, J .

PHYTOCHEMISTRY, 1987, 26 (11) :3075-3077

[8] SESQUITERPENE ARYL ESTERS FROM ARMILLARIA-MELLEA [J].

DONNELLY, DMX ;

HUTCHINSON, RM ;

COVENEY, D ;

YONEMITSU, M .

PHYTOCHEMISTRY, 1990, 29 (08) :2569-2572

[9]

Gao LW, 2009, AFR J BIOTECHNOL, V8, P7383

[10] Bioactive Sesquiterpene Aryl Esters from the Culture Broth of Armillaria sp. [J].

Kobori, Hajime ;

Sekiya, Atsushi ;

Suzuki, Tomohiro ;

Choi, Jae-Hoon ;

Hirai, Hirofumi ;

Kawagishi, Hirokazu .

JOURNAL OF NATURAL PRODUCTS, 2015, 78 (01) :163-167

← 1 2 →