PRORP proteins support RNase P activity in both organelles and the nucleus in Arabidopsis

被引：105

作者：

Gutmann, Bernard ^{[1
]}

Gobert, Anthony ^{[1
]}

Giege, Philippe ^{[1
]}

机构：

[1] Univ Strasbourg, CNRS, Inst Biol Mol Plantes, F-67084 Strasbourg, France

来源：

GENES & DEVELOPMENT | 2012年 / 26卷 / 10期

关键词：

RNase P; tRNA maturation; RNA processing; pentatricopeptide repeat; plant; SMALL NUCLEOLAR RNAS; GENE-EXPRESSION; PLANT; THALIANA; IDENTIFICATION; HOLOENZYME; MATURATION; PATHWAYS;

D O I：

10.1101/gad.189514.112

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

RNase P is an essential enzyme that cleaves the 59 leader sequence of tRNA precursors. RNase Ps were believed until now to occur universally as ribonucleoproteins in organisms performing RNase P activity. Here we find that protein-only RNase P enzymes called PRORP (for proteinaceous RNase P) support RNase P activity in vivo in both organelles and the nucleus in Arabidopsis. Beyond tRNA, PRORP proteins are involved in the maturation of small nucleolar RNA (snoRNA) and mRNA. Finally, ribonucleoprotein RNase MRP is not involved in tRNA maturation in plants. Altogether, our results indicate that ribonucleoprotein enzymes have been entirely replaced by proteins for RNase P activity in plants.

引用

页码：1022 / 1027

页数：6

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