Atropoisomeric (P,N) Ligands for the Highly Enantioselective Pd-Catalyzed Intramolecular Asymmetric a-Arylation of a-Branched Aldehydes

被引：67
|
作者：
Nareddy, Pradeep [1 ]
Mantilli, Luca [1 ]
Guenee, Laure [2 ]
Mazet, Clement [1 ]
机构：
[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland
[2] Univ Geneva, Lab Cristallog, CH-1211 Geneva 4, Switzerland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 16期
基金：
瑞士国家科学基金会;
关键词：
a-arylation; asymmetric catalysis; ligand design; oxidative addition; palladium; PRIMARY ALLYLIC ALCOHOLS; ALPHA-ARYLATION; ARYL HALIDES; REDUCTIVE ELIMINATION; RHODIUM COMPLEX; ALKYLATION; HYDROFORMYLATION; ISOMERIZATION; EFFICIENT; ORGANOCATALYSIS;
D O I：
10.1002/anie.201108061
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Three-in-one: A short synthetic route readily gives access to a new class of chiral (P,N) ligands characterized by three distinct elements of chirality. These ligands are highly enantioselective in the challenging Pd-catalyzed intramolecular asymmetric α-arylation of α-branched aldehydes (see picture). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：3826 / 3831
页数：6
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