Ischemia-induced neural stem/progenitor cells express pyramidal cell markers

被引：3

作者：

Clausen, Martijn ^{[1
]}

Nakagomi, Takayuki ^{[1
]}

Nakano-Doi, Akiko ^{[1
]}

Saino, Orie ^{[1
]}

Takata, Masashi ^{[1
]}

Taguchi, Akihiko ^{[2
]}

Luiten, Paul ^{[3
]}

Matsuyama, Tomohiro ^{[1
]}

机构：

[1] Hyogo Coll Med, Inst Adv Med Sci, Nishinomiya, Hyogo 6638501, Japan

[2] Natl Cardiovasc Res Ctr, Dept Cerebrovasc Dis, Osaka, Japan

[3] Univ Groningen, Univ Med Ctr Groningen, Ctr Life Sci, NL-9700 AB Groningen, Netherlands

来源：

NEUROREPORT | 2011年 / 22卷 / 16期

关键词：

mice; neural stem cells; neurogenesis; pyramidal neurons; stroke; CEREBRAL-CORTEX; STEM-CELLS; SUBCORTICAL TARGETS; CORTICAL-NEURONS; PROGENITOR CELLS; PROLIFERATION; NEUROGENESIS; BRAIN; TRANSLOCATION; ASTROCYTES;

D O I：

10.1097/WNR.0b013e32834acb54

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Adult brain-derived neural stem cells have acquired a lot of interest as an endurable neuronal cell source that can be used for central nervous system repair in a wide range of neurological disorders such as ischemic stroke. Recently, we identified injury-induced neural stem/progenitor cells in the poststroke murine cerebral cortex. In this study, we show that, after differentiation in vitro, injury-induced neural stem/progenitor cells express pyramidal cell markers Emx1 and CaMKII alpha, as well as mature neuron markers MAP2 and Tuj1. 5-bromo-2-deoxyuridinine-positive neurons in the peristroke cortex also express such pyramidal markers. The presence of newly regenerated pyramidal neurons in the poststroke brain might provide a noninvasive therapeutic strategy for stroke treatment with functional recovery. NeuroReport 22:789-794 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：789 / 794

页数：6

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