Ischemia-induced neural stem/progenitor cells express pyramidal cell markers

被引：3
作者：
Clausen, Martijn [1 ]
Nakagomi, Takayuki [1 ]
Nakano-Doi, Akiko [1 ]
Saino, Orie [1 ]
Takata, Masashi [1 ]
Taguchi, Akihiko [2 ]
Luiten, Paul [3 ]
Matsuyama, Tomohiro [1 ]
机构：
[1] Hyogo Coll Med, Inst Adv Med Sci, Nishinomiya, Hyogo 6638501, Japan
[2] Natl Cardiovasc Res Ctr, Dept Cerebrovasc Dis, Osaka, Japan
[3] Univ Groningen, Univ Med Ctr Groningen, Ctr Life Sci, NL-9700 AB Groningen, Netherlands
来源：
NEUROREPORT | 2011年 / 22卷 / 16期
关键词：
mice; neural stem cells; neurogenesis; pyramidal neurons; stroke; CEREBRAL-CORTEX; STEM-CELLS; SUBCORTICAL TARGETS; CORTICAL-NEURONS; PROGENITOR CELLS; PROLIFERATION; NEUROGENESIS; BRAIN; TRANSLOCATION; ASTROCYTES;
D O I：
10.1097/WNR.0b013e32834acb54
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Adult brain-derived neural stem cells have acquired a lot of interest as an endurable neuronal cell source that can be used for central nervous system repair in a wide range of neurological disorders such as ischemic stroke. Recently, we identified injury-induced neural stem/progenitor cells in the poststroke murine cerebral cortex. In this study, we show that, after differentiation in vitro, injury-induced neural stem/progenitor cells express pyramidal cell markers Emx1 and CaMKII alpha, as well as mature neuron markers MAP2 and Tuj1. 5-bromo-2-deoxyuridinine-positive neurons in the peristroke cortex also express such pyramidal markers. The presence of newly regenerated pyramidal neurons in the poststroke brain might provide a noninvasive therapeutic strategy for stroke treatment with functional recovery. NeuroReport 22:789-794 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码：789 / 794
页数：6
相关论文
共 21 条
[1]   Emx1 is a marker for pyramidal neurons of the cerebral cortex [J].
Chan, CH ;
Godinho, LN ;
Thomaidou, D ;
Tan, SS ;
Gulisano, M ;
Parnavelas, JG .
CEREBRAL CORTEX, 2001, 11 (12) :1191-1198
[2]   Subventricular zone astrocytes are neural stem cells in the adult mammalian brain [J].
Doetsch, F ;
Caillé, I ;
Lim, DA ;
García-Verdugo, JM ;
Alvarez-Buylla, A .
CELL, 1999, 97 (06) :703-716
[3]   Activation of dopamine D4 receptors induces synaptic translocation of Ca2+/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons [J].
Gu, ZL ;
Jiang, QA ;
Yuen, EY ;
Yan, Z .
MOLECULAR PHARMACOLOGY, 2006, 69 (03) :813-822
[4]   Primate embryonic stem cell-derived neuronal progenitors transplanted into ischemic brain [J].
Hayashi, Junya ;
Takagi, Yasushi ;
Fukuda, Hitoshi ;
Imazato, Takayuki ;
Nishimura, Masaki ;
Fujimoto, Motoaki ;
Takahashi, Jun ;
Hashimoto, Nobuo ;
Nozaki, Kazuhiko .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2006, 26 (07) :906-914
[5]   Enriched environment enhances transplanted subventricular zone stem cell migration and functional recovery after stroke [J].
Hicks, A. U. ;
Hewlett, K. ;
Windle, V. ;
Chernenko, G. ;
Ploughman, M. ;
Jolkkonen, J. ;
Weiss, S. ;
Corbett, D. .
NEUROSCIENCE, 2007, 146 (01) :31-40
[6]   Murine Embryonic Stem Cell-Derived Pyramidal Neurons Integrate into the Cerebral Cortex and Appropriately Project Axons to Subcortical Targets [J].
Ideguchi, Makoto ;
Palmer, Theo D. ;
Recht, Lawrence D. ;
Weimann, James M. .
JOURNAL OF NEUROSCIENCE, 2010, 30 (03) :894-904
[7]   Induction of neurogenesis in nonconventional neurogenic regions of the adult central nervous system by niche astrocyte-produced signals [J].
Jiao, Jianwei ;
Chen, Dong Feng .
STEM CELLS, 2008, 26 (05) :1221-1230
[8]   Adult neural stem and progenitor cells modified to secrete GDNF can protect, migrate and integrate after intracerebral transplantation in rats with transient forebrain ischemia [J].
Kameda, M. ;
Shingo, T. ;
Takahashi, K. ;
Muraoka, K. ;
Kurozumi, K. ;
Yasuhara, T. ;
Maruo, T. ;
Tsuboi, T. ;
Uozumi, T. ;
Matsui, T. ;
Miyoshi, Y. ;
Hamada, H. ;
Date, I. .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2007, 26 (06) :1462-1478
[9]  
Kuhn HG, 1996, J NEUROSCI, V16, P2027
[10]  
Lavdas AA, 1999, J NEUROSCI, V19, P7881
123