Embryonic stem cells: Understanding their history, cell biology and signalling

被引：34

作者：

Friel, R ^{[1
]}

van der Sar, S ^{[1
]}

Mee, PJ ^{[1
]}

机构：

[1] Stem Cell Sci Ltd, Edinburgh EH9 3JG, Midlothian, Scotland

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2005年 / 57卷 / 13期

关键词：

embryonic; stem cell; history; biology; signalling; review; drug discovery; toxicology; cell therapy;

D O I：

10.1016/j.addr.2005.08.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Embryonic Stem cells offer enormous potential as a source of a variety of differentiated cells for cell therapy, drug discovery and toxicology screening. With the creation of human embryonic stem cell lines we now have a resource with the potential to differentiate into every tissue of the body. To fully harness this resource it is necessary to understand their biology. Here we give a background to their history, describe interesting elements of their cell biology and introduce the underlying signalling mechanisms that control their ability to self-renew and differentiate. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：1894 / 1903

页数：10

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