Embryonic stem cells: Understanding their history, cell biology and signalling

被引：34
作者：
Friel, R [1 ]
van der Sar, S [1 ]
Mee, PJ [1 ]
机构：
[1] Stem Cell Sci Ltd, Edinburgh EH9 3JG, Midlothian, Scotland
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2005年 / 57卷 / 13期
关键词：
embryonic; stem cell; history; biology; signalling; review; drug discovery; toxicology; cell therapy;
D O I：
10.1016/j.addr.2005.08.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Embryonic Stem cells offer enormous potential as a source of a variety of differentiated cells for cell therapy, drug discovery and toxicology screening. With the creation of human embryonic stem cell lines we now have a resource with the potential to differentiate into every tissue of the body. To fully harness this resource it is necessary to understand their biology. Here we give a background to their history, describe interesting elements of their cell biology and introduce the underlying signalling mechanisms that control their ability to self-renew and differentiate. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：1894 / 1903
页数：10
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