Glycyrrhizin Suppresses the Growth of Human NSCLC Cell Line HCC827 by Downregulating HMGB1 Level

被引：33

作者：

Wu, Xiaojin ^{[1
]}

Wang, Weitao ^{[2
]}

Chen, Yuanyuan ^{[1
]}

Liu, Xiangqun ^{[3
]}

Wang, Jindong ^{[4
]}

Qin, Xiaobin ^{[5
]}

Yuan, Dawei ^{[2
]}

Yu, Tao ^{[5
]}

Chen, Guangxia ^{[6
]}

Mi, Yanyan ^{[7
]}

Mou, Jie ^{[7
]}

Cui, Jinpeng ^{[8
]}

Hu, Ankang ^{[9
]}

Yunxiang, E. ^{[5
]}

Pei, Dongsheng ^{[10
]}

机构：

[1] First Peoples Hosp Xuzhou, Dept Radiat Oncol, Xuzhou 221002, Jiangsu, Peoples R China

[2] Genesis Beijing Co Ltd, Beijing 100102, Peoples R China

[3] First Peoples Hosp Xuzhou, Dept Resp Dis, Xuzhou 221002, Jiangsu, Peoples R China

[4] First Peoples Hosp Xuzhou, Dept Chest Surg, Xuzhou 221002, Jiangsu, Peoples R China

[5] First Peoples Hosp Xuzhou, Dept Tumor, Xuzhou 221002, Jiangsu, Peoples R China

[6] First Peoples Hosp Xuzhou, Dept Gastroenterol, Xuzhou 221002, Jiangsu, Peoples R China

[7] Xuzhou Med Coll, Dept Pharm, Xuzhou 221004, Jiangsu, Peoples R China

[8] Yantaishan Hosp, Clin Lab, 91 Jiefang Rd, Yantai 264001, Shandong, Peoples R China

[9] Xuzhou Med Coll, Lab Anim Ctr, Xuzhou 221004, Jiangsu, Peoples R China

[10] Xuzhou Med Coll, Dept Pathol, Xuzhou 221004, Jiangsu, Peoples R China

来源：

BIOMED RESEARCH INTERNATIONAL | 2018年 / 2018卷

关键词：

MOBILITY GROUP BOX-1; NEO-MINOPHAGEN-C; LUNG-CANCER; PROTEIN; PROGRESSION; INHIBITION; INVASION; INJURY;

D O I：

10.1155/2018/6916797

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Lung cancer has very high mortality and glycyrrhizin was found to significantly inhibit the growth of lung cancer cells in vitro and tissues in mice. However, the detailed inhibitory role of glycyrrhizin in the growth of lung cancer is still unclear. In this study, we first found that glycyrrhizin inhibited the growth of lung tumor in PDX mice. And high level of HMGB1 promoted the migration and invasion of lung cancer cells, which was suppressed by glycyrrhizin. Moreover, glycyrrhizin reduced the activity of JAK/STAT signaling pathway, which is the upstream regulator of HMGB1. Therefore, this study revealed a potential mechanism by which glycyrrhizin can inhibit the progression of lung cancer.

引用

页数：7

共 38 条

[1] A road map for those who don't know JAK-STAT
Aaronson, DS
Horvath, CM
[J]. SCIENCE, 2002, 296 (5573) : 1653 - 1655
[2] RETRACTED: Targeting HMGB1 inhibits ovarian cancer growth and metastasis by lentivirus-mediated RNA interference (Retracted article. See vol. 230, pg. 2579, 2015)
Chen, Jie
Liu, Xiaoyan
Zhang, Jie
Zhao, Yueran
[J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2012, 227 (11) : 3629 - 3638
[3] Choi YR, 2003, CANCER RES, V63, P2188
[4] HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression
Curtin, James F.
Liu, Naiyou
Candolfi, Marianela
Xiong, Weidong
Assi, Hikmat
Yagiz, Kader
Edwards, Matthew R.
Michelsen, Kathrin S.
Kroeger, Kurt M.
Liu, Chunyan
Muhammad, A. K. M. Ghulam
Clark, Mary C.
Arditi, Moshe
Comin-Anduix, Begonya
Ribas, Antoni
Lowenstein, Pedro R.
Castro, Maria G.
[J]. PLOS MEDICINE, 2009, 6 (01) : 83 - 104
[5] Effects of Glycyrrhizin in a Mouse Model of Lung Adenocarcinoma
Deng, Qing-Ping
Wang, Mao-Jie
Zeng, Xing
Chen, George Gong
Huang, Run-Yue
[J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2017, 41 (04) : 1383 - 1392
[6] Elsam J, 2016, BIOTECH HISTOCHEM, V91, P145
[7] The effect of HMGB1 on the clinicopathological and prognostic features of non-small cell lung cancer
Feng, Anlin
Tu, Zhenbo
Yin, Bingjiao
[J]. ONCOTARGET, 2016, 7 (15) : 20507 - 20519
[8] Glycyrrhizin Suppresses Lung Adenocarcinoma Cell Growth Through Inhibition of Thromboxane Synthase
Huang, Run-Yue
Chu, Yong-Liang
Jiang, Ze-Bo
Chen, Xiu-Ming
Zhang, Xian
Zeng, Xing
[J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2014, 33 (02) : 375 - 388
[9] The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis (Publication with Expression of Concern. See vol. 129, pg. 1802, 2019)
Huebener, Peter
Pradere, Jean-Philippe
Hernandez, Celine
Gwak, Geum-Youn
Caviglia, Jorge Matias
Mu, Xueru
Loike, John D.
Jenkins, Rosalind E.
Antoine, Daniel J.
Schwabe, Robert F.
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (02) : 539 - 550
[10] Therapeutic effects of stronger neo-minophagen C at different doses on chronic hepatitis and liver cirrhosis
Iino, S
Tango, T
Matsushima, T
Toda, G
Miyake, K
Hino, K
Kumada, H
Yasuda, K
Kuroki, T
Hirayama, C
Suzuki, H
[J]. HEPATOLOGY RESEARCH, 2001, 19 (01) : 31 - 40

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