Influenza vaccine effectiveness among adult patients in a University of Lyon hospital (2004-2009)

被引：8

作者：

Amour, Selilah ^{[2
]}

Voirin, Nicolas ^{[1
,2
]}

Regis, Corinne ^{[2
]}

Bouscambert-Duchamp, Maude ^{[3
,4
]}

Comte, Brigitte ^{[5
]}

Coppere, Brigitte ^{[6
]}

Pires-Cronenberger, Silene ^{[1
]}

Lina, Bruno ^{[3
,4
]}

Vanhems, Philippe ^{[1
,2
]}

机构：

[1] Hosp Civils Lyon, Serv Hyg Epidemiol & Prevent, Hop Edouard Herriot, F-69437 Lyon 03, France

[2] Univ Lyon 1, CNRS UMR 5558, Lab Biometrie & Biol Evolut, F-69365 Lyon, France

[3] Univ Lyon 1, VIRPATH, CNRS FRE 3011, Bron, France

[4] Hosp Civils Lyon, Grp Hosp Est, Virol Lab, Bron, France

[5] Hosp Civils Lyon, Hop Edouard Herriot, Serv Geriatrie, F-69437 Lyon 03, France

[6] Hosp Civils Lyon, Hop Edouard Herriot, Serv Med Interne, F-69437 Lyon 03, France

来源：

VACCINE | 2012年 / 30卷 / 05期

关键词：

Influenza; Influenza vaccine; Vaccine effectiveness; Mismatch; INFECTION; DESIGNS; SEASON;

D O I：

10.1016/j.vaccine.2011.11.033

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The aim of this study was to estimate influenza vaccine effectiveness (IVE) against laboratory-confirmed influenza among hospitalized patients. A case-control investigation was based on the prospective surveillance of influenza-like illness (ILI) during five flu seasons. We compared influenza-positive cases and influenza-negative controls. Unadjusted overall IVE was 62% (95% confidence interval 24% to 81%). We found that WE was lower during the 2004-05 flu season (11%; 95% Cl -232% to 76%) when the vaccine and circulating viruses were mismatched. Expansion of the study to other hospitals could provide IVE estimates earlier in the season, for different age groups and emerging virus strains. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：821 / 824

页数：4

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