Leptin in Depressive Episodes: Is There a Difference between Unipolar and Bipolar Depression?

被引：20
作者：
Cordas, Gisele [1 ]
Gazal, Marta [1 ]
Schuch, Eduardo M. [1 ]
Spessato, Barbara C. [1 ]
Branco, Jeronimo [1 ]
Jansen, Karen [1 ]
Oses, Jean P. [1 ]
Quevedo, Luciana A. [1 ]
Souza, Luciano D. M. [1 ]
Pinheiro, Ricardo T. [1 ]
Portela, Luiz Valmor [3 ]
da Silva, Ricardo A. [1 ]
Lara, Diogo R. [2 ]
Kaster, Manuella P. [1 ]
Ghisleni, Gabriele [1 ]
机构：
[1] Univ Catolic Pelotas, Ctr Ciencias Vida & Saude, Programa Posgrad Saude & Comportamento, BR-96015560 Pelotas, RS, Brazil
[2] Pontificia Univ Catolica Rio Grande do Sul, Biol Celular & Mol, Porto Alegre, RS, Brazil
[3] Univ Fed Rio Grande do Sul, Dept Bioquim, Porto Alegre, RS, Brazil
来源：
NEUROENDOCRINOLOGY | 2015年 / 101卷 / 01期
关键词：
Current depressive episode; Unipolar depression; Bipolar depression; Leptin; OBESITY; WOMEN;
D O I：
10.1159/000371803
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: The present study investigated whether peripheral leptin levels are associated with current depressive episodes in a cross-sectional study nested within a population-based study. Methods: The Mini-International Neuropsychiatric Interview (MINI) 5.0 was used to assess the presence of current depressive episodes. The sample was composed of 206 subjects (103 controls and 103 subjects with a current depressive episode) paired by gender, BMI and age. Medication use and lifestyle characteristics were self-reported. Results: Serum leptin levels were lower in currently depressive subjects (10.9 +/- 12.0 ng/ml) than in the control group (20.3 +/- 24.0 ng/ml; p = 0.023). According to the clinical diagnosis, individuals with bipolar depression present lower leptin levels (8.4 +/- 8.1 ng/ml) than those with unipolar depression (12.0 +/- 13.4 ng/ml) and the control group (20.3 +/- 24.0 ng/ml; p = 0.031). In addition, ANCOVA showed that leptin is an independent factor associated with current depressive episodes (p = 0.018). Conclusion: A decreased leptin level might be a useful peripheral marker associated with depressive episodes in the context of bipolar disorder. (C) 2015 S. Karger AG, Basel
引用
收藏
页码：82 / 86
页数：5
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