Liquid biopsies and tumor mutational burden: the cutoff conundrum

被引：2
|
作者：
Kasi, Pashtoon Murtaza [1 ]
机构：
[1] Weill Cornell Med, Meyer Canc Ctr, Englander Inst Precis Med, New York, NY 10021 USA
来源：
NATURE MEDICINE | 2022年 / 28卷 / 09期
关键词：
D O I：
10.1038/s41591-022-01999-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Assessment of tumor mutational burden through a simple blood test could help to identify which patients are most likely to benefit from immunotherapy, but optimal cutoffs are not well established.
引用
收藏
页码：1753 / 1754
页数：2
相关论文
共 50 条
  • [21] MSI and Tumor Mutational Burden in Colorectal Cancer
    Kuetting, Fabian
    Bludau, Marc
    Alakus, Hakan
    Bruns, Christiane
    ONKOLOGE, 2019, 25 (09): : 829 - 830
  • [22] Tumor purity as confounder for the determination of tumor mutational burden (TMB)
    Beck, Susanne
    Menzel, Michael
    Kazdal, Daniel
    Schirmacher, Peter
    Stenzinger, Albrecht
    Budczies, Jan
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [23] Tumor Mutational Burden in Wilms Tumor (WT): A Pilot Study
    Mattis, Aidas
    Love-Gregory, Latisha
    McNulty, Samantha
    Pfeifer, John
    Dehner, Louis
    He, Mai
    LABORATORY INVESTIGATION, 2019, 99
  • [24] Tumor Mutational Burden in Wilms Tumor (WT): A Pilot Study
    Mattis, Aidas
    Love-Gregory, Latisha
    McNulty, Samantha
    Pfeifer, John
    Dehner, Louis
    He, Mai
    MODERN PATHOLOGY, 2019, 32
  • [25] Intra-patient stability of tumor mutational burden from tissue biopsies at different time points in advanced cancers
    Pham, Timothy V.
    Goodman, Aaron M.
    Sivakumar, Smruthy
    Frampton, Garrett
    Kurzrock, Razelle
    GENOME MEDICINE, 2021, 13 (01)
  • [26] Intra-patient stability of tumor mutational burden from tissue biopsies at different time points in advanced cancers
    Timothy V. Pham
    Aaron M. Goodman
    Smruthy Sivakumar
    Garrett Frampton
    Razelle Kurzrock
    Genome Medicine, 13
  • [27] Tumor mutational burden standardization initiatives: Recommendations for consistent tumor mutational burden assessment in clinical samples to guide immunotherapy treatment decisions
    Stenzinger, Albrecht
    Allen, Jeffrey D.
    Maas, Joerg
    Stewart, Mark D.
    Merino, Diana M.
    Wempe, Madison M.
    Dietel, Manfred
    GENES CHROMOSOMES & CANCER, 2019, 58 (08): : 578 - 588
  • [28] Determinants of high tumor mutational burden (TMB) and mutational signatures in breast cancer
    Barroso-Sousa, Romualdo
    Jain, Esha
    Kim, Dewey
    Partridge, Ann H.
    Cohen, Ofir
    Wagle, Nikhil
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
  • [29] Tumor mutational burden and efficacy of chemotherapy in lung cancer
    Juan Song
    Yu Yan
    Cuicui Chen
    Jiamin Li
    Ning Ding
    Nuo Xu
    Hairong Bao
    Xin Zhang
    Qunying Hong
    Jian Zhou
    Yang W. Shao
    Yuanlin Song
    Lin Tong
    Jie Hu
    Clinical and Translational Oncology, 2023, 25 : 173 - 184
  • [30] Melanoma Tumor Mutational Burden and Indoor Tanning Exposure
    Hanrahan, Grace B.
    Giobbie-Hurder, Anita
    Allais, Blair
    Vogelzang, Jayne
    Fay, Christopher
    Tsibris, Hillary C.
    JAMA DERMATOLOGY, 2025, 161 (02) : 198 - 202
12345