Global Sensitivity Approach for the Human Immunodeficiency Virus Pathogenesis with Cytotoxic T-Lymphocytes and Infected Cells in Eclipse Phase

被引：0
|
作者：
Dimitriu, Gabriel [1 ]
Boiculese, Vasile Lucian [1 ]
Moscalu, Mihaela [1 ]
Dascalu, Cristina Gena [1 ]
机构：
[1] Grigore T Popa Univ Med & Pharm, Dept Prevent Med & Interdisciplinar, Iasi, Romania
来源：
2019 E-HEALTH AND BIOENGINEERING CONFERENCE (EHB) | 2019年
关键词：
ordinary differential equation; HIV pathogenesis; cytotoxic T-lymphocytes; sensitivity heat map; parameter sensitivity spectrum; HIV-INFECTION; DYNAMICS; STABILITY; MODELS;
D O I：
10.1109/ehb47216.2019.8969898
中图分类号：
R19 [保健组织与事业（卫生事业管理）];
学科分类号：
摘要：
The aim of the study is to perform a global sensitivity analysis for a model describing the HIV pathogenesis with cytotoxic T-lymphocytes and infected cells in eclipse phase. The viral dynamics of the model is defined by a system of five ordinary differential equations defining rates of variation for the cell populations. The global sensitivity is carried out by sensitivity heat maps and parameter sensitivity spectra generated for several scenarios corresponding to infection-free and endemic equilibria.
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页数：5
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