Regulation of Proteolysis in the Gram-Negative Bacterial Envelope

被引：7

作者：

Raivio, Tracy L. ^{[1
]}

机构：

[1] Univ Alberta, Dept Biol Sci, Edmonton, AB, Canada

来源：

JOURNAL OF BACTERIOLOGY | 2018年 / 200卷 / 03期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

DegP; Escherichia coli; Gram negative; YjfN; bacterial envelope; proteolysis; stress response; STRESS-RESPONSE; QUALITY-CONTROL; MEMBRANE PROTEINS; PLASMA-MEMBRANE; SUBSTRATE; DEGRADATION; PROTEASES; COMPLEX; DEGP; ACTIVATION;

D O I：

10.1128/JB.00639-17

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Proteolysis is carefully regulated to prevent the untimely destruction of critical proteins. In this issue of the Journal of Bacteriology, Kim and colleagues identify YjfN as a proteolytic regulator that stimulates the activity of the DegP/HtrA protease of Escherichia coli (S. Kim, I. Song, G. Eom, and S. Kim, J Bacteriol 200:e00519-17, 2018, https://doi.org/10.1128/JB.00519-17). The suicide destruction and transcriptional regulation of YjfN limit its activity to conditions in which there are likely to be many misfolded substrate proteins present.

引用

页数：6

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