Proteolysis is carefully regulated to prevent the untimely destruction of critical proteins. In this issue of the Journal of Bacteriology, Kim and colleagues identify YjfN as a proteolytic regulator that stimulates the activity of the DegP/HtrA protease of Escherichia coli (S. Kim, I. Song, G. Eom, and S. Kim, J Bacteriol 200:e00519-17, 2018, https://doi.org/10.1128/JB.00519-17). The suicide destruction and transcriptional regulation of YjfN limit its activity to conditions in which there are likely to be many misfolded substrate proteins present.
机构:
Normandy Univ, Rouen Normandy Univ, Res Unit Bacterial Commun & Antiinfect Strategies, 55 Rue St Germain, F-27000 Evreux, FranceNormandy Univ, Rouen Normandy Univ, Res Unit Bacterial Commun & Antiinfect Strategies, 55 Rue St Germain, F-27000 Evreux, France
Chautrand, Thibault
Souak, Djouhar
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Normandy Univ, Rouen Normandy Univ, Res Unit Bacterial Commun & Antiinfect Strategies, 55 Rue St Germain, F-27000 Evreux, FranceNormandy Univ, Rouen Normandy Univ, Res Unit Bacterial Commun & Antiinfect Strategies, 55 Rue St Germain, F-27000 Evreux, France
Souak, Djouhar
Chevalier, Sylvie
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Normandy Univ, Rouen Normandy Univ, Res Unit Bacterial Commun & Antiinfect Strategies, 55 Rue St Germain, F-27000 Evreux, FranceNormandy Univ, Rouen Normandy Univ, Res Unit Bacterial Commun & Antiinfect Strategies, 55 Rue St Germain, F-27000 Evreux, France
Chevalier, Sylvie
Duclairoir-Poc, Cecile
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Normandy Univ, Rouen Normandy Univ, Res Unit Bacterial Commun & Antiinfect Strategies, 55 Rue St Germain, F-27000 Evreux, FranceNormandy Univ, Rouen Normandy Univ, Res Unit Bacterial Commun & Antiinfect Strategies, 55 Rue St Germain, F-27000 Evreux, France
机构:
Bioharmony Therapeut, New York, NY 10016 USABioharmony Therapeut, New York, NY 10016 USA
Ghose, Chandrabali
Euler, Chad W.
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CUNY Hunter Coll, Dept Med Lab Sci, New York, NY 10065 USA
Weill Cornell Med, Dept Microbiol & Immunol, New York, NY 10065 USABioharmony Therapeut, New York, NY 10016 USA
机构:
Kerman Univ Med Sci, Med Mycol & Bacteriol Res Ctr, Kerman 7616913555, IranKerman Univ Med Sci, Med Mycol & Bacteriol Res Ctr, Kerman 7616913555, Iran
Barani, Mahmood
Zeeshan, Mahira
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Quaid I Azam Univ, Fac Biol Sci, Dept Pharm, Islamabad 45320, PakistanKerman Univ Med Sci, Med Mycol & Bacteriol Res Ctr, Kerman 7616913555, Iran
Zeeshan, Mahira
Kalantar-Neyestanaki, Davood
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Kerman Univ Med Sci, Med Mycol & Bacteriol Res Ctr, Kerman 7616913555, Iran
Kerman Univ Med Sci, Afzalipour Fac Med, Dept Med Microbiol Bacteriol & Virol, Kerman 7616913555, IranKerman Univ Med Sci, Med Mycol & Bacteriol Res Ctr, Kerman 7616913555, Iran
Kalantar-Neyestanaki, Davood
Farooq, Muhammad Asim
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Univ Lahore, Fac Pharm, Dept Pharmaceut, Lahore 54000, PakistanKerman Univ Med Sci, Med Mycol & Bacteriol Res Ctr, Kerman 7616913555, Iran
Farooq, Muhammad Asim
Rahdar, Abbas
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Univ Zabol, Dept Phys, Zabol 9861335856, IranKerman Univ Med Sci, Med Mycol & Bacteriol Res Ctr, Kerman 7616913555, Iran
Rahdar, Abbas
Jha, Niraj Kumar
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Sharda Univ, Sch Engn & Technol, Dept Biotechnol, Greater Noida 201310, IndiaKerman Univ Med Sci, Med Mycol & Bacteriol Res Ctr, Kerman 7616913555, Iran
Jha, Niraj Kumar
Sargazi, Saman
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Zahedan Univ Med Sci, Res Inst Cellular & Mol Sci Infect Dis, Cellular & Mol Res Ctr, Zahedan 9816743463, IranKerman Univ Med Sci, Med Mycol & Bacteriol Res Ctr, Kerman 7616913555, Iran
Sargazi, Saman
Gupta, Piyush Kumar
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Sharda Univ, Sch Basic Sci & Res, Dept Life Sci, Greater Noida 201310, IndiaKerman Univ Med Sci, Med Mycol & Bacteriol Res Ctr, Kerman 7616913555, Iran
Gupta, Piyush Kumar
Thakur, Vijay Kumar
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Biorefining & Adv Mat Res Ctr, SRUC, Edinburgh EH9 3JG, Midlothian, Scotland
Shiv Nadar Univ, Sch Engn, Dept Mech Engn, Greater Noida 201314, India
Univ Petr & Energy Studies UPES, Sch Engn, Dehra Dun 248007, Uttarakhand, IndiaKerman Univ Med Sci, Med Mycol & Bacteriol Res Ctr, Kerman 7616913555, Iran