Cell communication networks in cancer invasion

被引：74
作者：
Calvo, Fernando [1 ]
Sahai, Erik [1 ]
机构：
[1] London Res Inst, Tumor Cell Biol Lab, London WC2A 3LY, England
来源：
CURRENT OPINION IN CELL BIOLOGY | 2011年 / 23卷 / 05期
关键词：
ADHESION MOLECULE L1; REGULATORY T-CELLS; TUMOR-CELLS; EXTRACELLULAR-MATRIX; TGF-BETA; TRANSENDOTHELIAL MIGRATION; DRUG-RESISTANCE; CARCINOMA-CELLS; MOUSE MODEL; TENASCIN-C;
D O I：
10.1016/j.ceb.2011.04.010
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The invasion of cancer is a major clinical problem. It is now apparent that invasion is not a simply a cancer cell autonomous process but relies on a complex network of paracrine interactions. Furthermore, this network can change as cancer cells disseminate. Here we summarise the key components of the network and their mechanisms of communication. Finally, we discuss the difficulties and opportunities that this complex network of interactions presents during cancer therapy.
引用
收藏
页码：621 / 629
页数：9
相关论文
共 87 条
  • [1] Competition amongst Eph receptors regulates contact inhibition of locomotion and invasiveness in prostate cancer cells
    Astin, Jonathan W.
    Batson, Jennifer
    Kadir, Shereen
    Charlet, Jessica
    Persad, Raj A.
    Gillatt, David
    Oxley, Jon D.
    Nobes, Catherine D.
    [J]. NATURE CELL BIOLOGY, 2010, 12 (12) : 1194 - U175
  • [2] Mechanisms of resistance to antiangiogenesis therapy
    Azam, Faisal
    Mehta, Shaveta
    Harris, Adrian L.
    [J]. EUROPEAN JOURNAL OF CANCER, 2010, 46 (08) : 1323 - 1332
  • [3] Cancer and the chemokine network
    Balkwill, F
    [J]. NATURE REVIEWS CANCER, 2004, 4 (07) : 540 - 550
  • [4] Inflammation-associated immune suppression in cancer: The roles played by cytokines, chemokines and additional mediators
    Ben-Baruch, A
    [J]. SEMINARS IN CANCER BIOLOGY, 2006, 16 (01) : 38 - 52
  • [5] TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
    Bhowmick, NA
    Chytil, A
    Plieth, D
    Gorska, AE
    Dumont, N
    Shappell, S
    Washington, MK
    Neilson, EG
    Moses, HL
    [J]. SCIENCE, 2004, 303 (5659) : 848 - 851
  • [6] Buckley CD, 1996, J CELL SCI, V109, P437
  • [7] A tense situation: forcing tumour progression
    Butcher, Darci T.
    Alliston, Tamara
    Weaver, Valerie M.
    [J]. NATURE REVIEWS CANCER, 2009, 9 (02) : 108 - 122
  • [8] Environmental control of invasiveness and metastatic dissemination of tumor cells: the role of tumor cell-host cell interactions
    Calorini, Lido
    Bianchini, Francesca
    [J]. CELL COMMUNICATION AND SIGNALING, 2010, 8
  • [9] Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    Casanovas, O
    Hicklin, DJ
    Bergers, G
    Hanahan, D
    [J]. CANCER CELL, 2005, 8 (04) : 299 - 309
  • [10] Dissemination and growth of cancer cells in metastatic sites
    Chambers, AF
    Groom, AC
    MacDonald, IC
    [J]. NATURE REVIEWS CANCER, 2002, 2 (08) : 563 - 572
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