Cell communication networks in cancer invasion

被引：76
作者：
Calvo, Fernando [1 ]
Sahai, Erik [1 ]
机构：
[1] London Res Inst, Tumor Cell Biol Lab, London WC2A 3LY, England
来源：
CURRENT OPINION IN CELL BIOLOGY | 2011年 / 23卷 / 05期
关键词：
ADHESION MOLECULE L1; REGULATORY T-CELLS; TUMOR-CELLS; EXTRACELLULAR-MATRIX; TGF-BETA; TRANSENDOTHELIAL MIGRATION; DRUG-RESISTANCE; CARCINOMA-CELLS; MOUSE MODEL; TENASCIN-C;
D O I：
10.1016/j.ceb.2011.04.010
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The invasion of cancer is a major clinical problem. It is now apparent that invasion is not a simply a cancer cell autonomous process but relies on a complex network of paracrine interactions. Furthermore, this network can change as cancer cells disseminate. Here we summarise the key components of the network and their mechanisms of communication. Finally, we discuss the difficulties and opportunities that this complex network of interactions presents during cancer therapy.
引用
收藏
页码：621 / 629
页数：9
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