Characterizing PEG Chains Tethered onto Micelles and Liposomes Applied as Drug Delivery Vehicles Using Scattering Techniques

被引：0
|
作者：
Fujii, Shota [1 ]
Sakuragi, Mina [2 ]
Sakurai, Kazuo [1 ]
机构：
[1] Sojo Univ, Fac Engn, Dept Nanosci, 4-22-1 Ikeda, Nishi, Kumamoto 8600082, Japan
[2] Univ Kitakyushu, Dept Chem & Biochem, Wakamatsu Ku, 1-1 Hibikino, Kitakyushu, Fukuoka 8080135, Japan
来源：
CONTROL OF AMPHIPHILE SELF-ASSEMBLING AT THE MOLECULAR LEVEL: SUPRA-MOLECULAR ASSEMBLIES WITH TUNED PHYSICOCHEMICAL PROPERTIES FOR DELIVERY APPLICATIONS | 2017年 / 1271卷
关键词：
BLOCK-COPOLYMER MICELLES; EXCLUDED-VOLUME INTERACTIONS; GLYCOL-COATED LIPOSOMES; SMALL-ANGLE NEUTRON; X-RAY-SCATTERING; PROLONGED CIRCULATION; POLYMERIC MICELLES; PHAGOCYTIC UPTAKE; PROTEIN-BINDING; NANOPARTICLES;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A polyethylene glycol (PEG)-coated surface provides biocompatibility to nanoparticles including polymeric micelles and liposomes for injectable drugs and other biomaterials. Although this technology seems well established and the term PEGylation is now commonly used, how to analyze it quantitatively, namely, determining how densely PEG chains are coated on the surface and its relationship to biocompatibility, is still not fully understood. This chapter reviews our recent studies of quantitative characterization of PEG chains tethered onto the nanoparticle surface by using light scattering and small-angle X-ray scattering.
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收藏
页码：115 / 129
页数：15
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