Anti-tumor action and clinical application of proteasome inhibitor

被引：1

作者：

Zhou Yong-ming ^{[2
]}

Yu Mei-xia ^{[2
]}

Long Hui ^{[2
]}

Huang Shi-ang ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Stem Cell Ctr, Wuhan 430022, Peoples R China

[2] Wuhan Univ Sci & Technol, Affiliated Hosp, Dept Hematol, Wuhan 430000, Peoples R China

来源：

CHINESE JOURNAL OF CANCER RESEARCH | 2008年 / 20卷 / 02期

关键词：

proteasome inhibitor; ubiquitin-proteasome pathway; tumor;

D O I：

10.1007/s11670-008-0077-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ubiquitin-proteasome pathway mediates the degradation of cell protein, and cell cycle, gene translation and expression, antigen presentation and inflammatory development. Proteasome inhibitor can inhibit growth and proliferation of tumor cell, induce apoptosis and reverse multipledrug resistance of tumor cell, increase the sensitivity of other chemotherapeutic drugs and radiotherapy, and is a novel class of potent anti-tumor agents.

引用

页码：77 / 84

页数：8

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