Review of research on quantitative structure-retention relationships in thin-layer chromatography

A review is given on the quantitative structure-retention relationship (QSRR) in TLC. The establishment of QSRR equations is described, which is based on physico-chemical parameters, non-specific parameters, topological indices, and a combination of physico-chemical parameters. The application of QSRR for prediction of retention, determination of lipophilicity, evaluation of some physico-chemical parameters of chemicals, evaluation of biological activity of compounds, and explanation of separation mechanisms are also reviewed.