Angiomatoid Fibrous Histiocytoma (AFH) of the Right Arm: An Exceptional Case with Pulmonary Metastasis and Confirmatory EWSR1::CREB1 Translocation

被引：4

作者：

Cazzato, Gerardo ^{[1
]}

Lupo, Carmelo ^{[2
]}

Casatta, Nadia ^{[2
]}

Riefoli, Flavia ^{[3
]}

Marzullo, Andrea ^{[1
]}

Colagrande, Anna ^{[1
]}

Cascardi, Eliano ^{[4
,5
]}

Trabucco, Senia Maria Rosaria ^{[1
]}

Ingravallo, Giuseppe ^{[1
]}

Moretti, Biagio ^{[3
]}

Maiorano, Eugenio ^{[1
]}

Pesce, Vito ^{[6
]}

Resta, Leonardo ^{[1
]}

机构：

[1] Univ Bari Aldo Moro, Sect Mol Pathol, Dept Emergency & Organ Transplantat DETO, I-70124 Bari, Italy

[2] Diapath SPA, Innovat Dept, Via Savoldini N 71, I-24057 Martinengo, Italy

[3] Univ Bari Aldo Moro, Sect Orthoped & Traumatol, Dept Basic Med Sci Neurosci & Sense Organs, I-70124 Bari, Italy

[4] Univ Turin, Dept Med Sci, I-10124 Turin, Italy

[5] FPO IRCCS Candiolo Canc Inst, Pathol Unit, Str Provinciale 142, I-10060 Candiolo, Italy

[6] Univ Foggia, Sect Orthoped & Traumatol, Dept Clin & Expt Med, I-71100 Foggia, Italy

来源：

DIAGNOSTICS | 2022年 / 12卷 / 11期

关键词：

angiomatoid fibrous histiocytoma; AFH; pulmonary metastasis; malignant; soft tissue; differential diagnosis;

D O I：

10.3390/diagnostics12112616

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Angiomatoid fibrous histiocytoma (AFH) is a rare neoplasm described for the first time by Enzinger in 1979, and classified by World Health Organization 2020 as intermediate malignant potential neoplasm. It mostly occurs in the subcutis and is characterized by varying proportions of epithelioid, ovoid and spindle cells in a nodular and syncytial growth pattern, with some hemorrhagic pseudovascular spaces. In this paper, we report the clinical case of a 62-year-old man who presented with AFH on the right arm, and relapsed three years after first surgical excision. After a further three years, the patient presented with an intramuscular localization of AFH, and 12 months after this, a pulmonary metastasis of AFH was diagnosed. Given the rarity of the spreading of AFH, we performed Fluorescence In Situ Hybridization (FISH) and we detected EWSR1::CREB1 gene fusion.

引用

页数：4

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